Extracellular matrix proteins involved in Alzheimer's disease.

Extracellular matrix proteins involved in Alzheimer's disease. Chemistry. 2020 Mar 23;: Authors: Ma J, Ma C, Li J, Sun Y, Ye F, Liu K, Zhang H Abstract Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and characterized by cognitive and memory impairments. Emerging evidence suggests that the extracellular matrix (ECM) biomacromolecules in brain plays an important role in etiology of AD. It has been detected that the levels of ECM proteins have been changed in the brains of AD patients and animal models. Some ECM components, e.g., elastin and heparan sulfate proteoglycans, are considered to promote the upregulation of extracellular amyloid-β (Aβ) proteins. In addition, collagen VI and laminin are shown to have interactions with Aβ peptides, which might lead to clearance of those peptides. Thus, ECM proteins are involved in both amyloidosis and neuroprotection in AD process. However, the molecular mechanism of neuronal ECM proteins on pathophysiology of AD remains elusive. More investigation of ECM proteins with AD pathogenesis is needed, and this may lead to novel therapeutic strategies and biomarkers for AD. PMID: 32207199 [PubMed - as supplied by publisher]
Source: Chemistry - Category: Chemistry Authors: Tags: Chemistry Source Type: research