Gut microbiota orchestrates PTH action in bone: role of butyrate and T cells

Parathyroid hormone (PTH) is an important regulator of bone remodeling. It has the capacity to stimulate both bone formation and bone resorption, two apparently opposite actions. Bone loss and increased bone fragility due to predominant bone resorption mainly occur when bone cells are exposed to PTH continuously, as is seen in primary and secondary hyperparathyroidism. In contrast, gain of bone mass and bone strength is observed in response to intermittent PTH release or administration, owing to more bone formation than resorption.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Digest Source Type: research