PSMA-PET/CT again shows prowess for prostate cancer

Prostate-specific membrane antigen (PMSA)-PET/CT could become the primary modality...Read more on AuntMinnie.comRelated Reading: PSMA-PET/CT most effective for recurrent prostate cancer SNMMI: PSMA-PET helps guide prostate cancer therapy Could Ga-68 PSMA PET become essential for prostate cancer? Ga-68 PSMA PET/CT for prostate wins Australian favor Ga-68 PSMA-11 PET/MRI improves prostate cancer detection
Source: Headlines - Category: Radiology Source Type: news

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The mechanisms by which prostate cancer shifts from an indolent castration-sensitive phenotype to lethal castration-resistant prostate cancer (CRPC) are poorly understood. Identification of clinically relevant genetic alterations leading to CRPC may reveal potential vulnerabilities for cancer therapy. Here we find that CUB domain-containing protein 1 (CDCP1), a transmembrane protein that acts as a substrate for SRC family kinases (SFKs), is overexpressed in a subset of CRPC. Notably, CDCP1 cooperates with the loss of the tumor suppressor gene PTEN to promote the emergence of metastatic prostate cancer. Mechanistically, we ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Abstract One of the major barriers in cancer therapy is the resistance to conventional therapies and cancer stem cells (CSCs) are among the main causes of this problem. CD133 as a CSC marker displays stem cell-like properties, tumorigenic capacity, and drug resistance in various cancers. However, the molecular mechanism behind CD133 function in prostate cancer (PC) still remains unclear. This research aimed to illustrate the probabilistic mechanism of CD133-siRNA and paclitaxel in the reduction of chemoresistance in PC cells. To measure the cell viability, migratory capacity, CSCs properties, invasive potential, a...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
In conclusion, the combination of ionizing radiation and oncolytic adenovirus expressing IL24 could achieve synergistic anti-tumor effect on prostate cancer, and is a promising strategy for prostate cancer therapy.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionThis is the first study evaluating the psychometric properties of the Caregiver FACT-G. More psychometric testing is warranted, especially among caregivers of diverse sociocultural backgrounds.
Source: Quality of Life Research - Category: Health Management Source Type: research
This DNA ‐based, DNA origami nanostructure (DON)‐enabled, cell‐selective, and biocompatible drug delivery platform with high “drug/ligand ratio” shows immense potential as an efficient drug carrier for developing novel nanomedicine with high pharmacokinetics and therapeutic index. AbstractEffective drug delivery systems that can systematically and selectively transport payloads to disease cells remain a challenge. Here, a targeting ligand ‐modified DNA origami nanostructure (DON) as an antibody–drug conjugate (ADC)‐like carrier for targeted prostate cancer therapy is reported. Specifically, DON ...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
Abstract The potential usage of cyanobacteria and microalgae as a promising and alternative source for new and safe therapeutic compounds is recently caught the attention, due to its versatile properties as antitumor, antioxidant, antifungal, and antiviral agents. Primarily, the cyanobacteria and microalgae from fresh and marine water are previously studied, however those isolated from soil and agriculture drain water were poorly investigated. Therefore, this study aimed to screen and characterize the antioxidant profile, as well as the potential anticancer assessment of 12 species of cyanobacteria and two species...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
CONCLUSIONS: This is the first study in which ANO7 interacting proteins have been identified. Although further studies are needed, the findings reported here expand our understanding of the role and regulation of ANO7 in prostate cancer cells. Furthermore, these results are likely to introduce new targets for the novel cancer therapies. PMID: 32176628 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
Enzalutamide (Enz) has shown limited bioavailability via oral administration. Castration-resistant prostate cancer (CRPC) is frequent among patients receiving 18 –24 months of androgen deprivation therapy. The ...
Source: Journal of Nanobiotechnology - Category: Nanotechnology Authors: Tags: Research Source Type: research
In this study, a new protocol involves three-component condensation of the 3-amino-1,2,4-triazole as a 1,3-binucleophile, versatile aldehydes and N-methyl-1-(methylthio)-2-nitroethenamine as an enamine analogous in the presence of trichloroacetic acid as a Brønsted-Lowry acidic promoter leads to new functionalized N-alkyl-6-nitro-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine in moderate to good yields. The presence of five nitrogen heteroatoms in the product structure has gathered immense attention among chemists and biologists due to their biological values. Therefore, we evaluated the anti-tumor activity of ...
Source: Bioorganic and Medicinal Chemistry Letters - Category: Chemistry Authors: Tags: Bioorg Med Chem Lett Source Type: research
Recent findings have shown that inhibitors targeting bromodomain and extraterminal domain (BET) proteins, such as the small molecule JQ1, are potent growth inhibitors of many cancers and hold promise for cancer therapy. However, some reports have also revealed that JQ1 can activate additional oncogenic pathways and may affect epithelial-to-mesenchymal transition (EMT). Therefore, it is important to address the potential unexpected effect of JQ1 treatment, such as cell invasion and metastasis. Here, we showed that in prostate cancer, JQ1 inhibited cancer cell growth but promoted invasion and metastasis in a BET protein&ndas...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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