Discovery of Anti-malarial Agents Through Application of In silico Studies.

Discovery of Anti-malarial Agents Through Application of In silico Studies.
Comb Chem High Throughput Screen. 2014 Dec 29;
Authors: Barmade MA, Murumkar PR, Sharma MK, Shingala KP, Giridhar RR, Yadav MR
Abstract
Among the various parasitic diseases, malaria is the deadliest one. Due to the emergence of high drug resistance to the existing drug candidates there is a global need for development of new drug candidates which will be effective against resistant strains of malaria parasite. In silico molecular modeling approaches have been playing an important role in the discovery of novel lead molecules having antimalarial activity. Present review is an effort to cover all the developments related to the application of computational techniques for the design and discovery of novel antimalarial compounds since the year 2011 onwards.
PMID: 25543680 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - December 29, 2014 Category: Chemistry Authors: Barmade MA, Murumkar PR, Sharma MK, Shingala KP, Giridhar RR, Yadav MR Tags: Comb Chem High Throughput Screen Source Type: research