Factors Affecting Trough Plasma Dabigatran Concentrations in Patients with Atrial Fibrillation and Chronic Kidney Disease
AbstractIntroductionDabigatran is effective and widely used to prevent ischemic stroke and systemic embolism (SE) in patients with atrial fibrillation (AF). Chronic kidney disease (CKD) also has implications for choice of any medications, as it alters pharmacokinetic parameters of drugs.AimTo evaluate trough plasma dabigatran concentration (DTPC) and to analyse potential factors affecting these values in patients with AF and CKD.MethodsPatients with AF and stage 3 CKD were treated with dabigatran 110 mg or 150 mg have been included in the study and allocated into D110 or D150 group. DTPC was evaluated with high-performance liquid chromatography. A plasma trough concentration/dose (C/D) ratio was used as a pharmacokinetic index. Factors affecting the DTPC were investigated.ResultsA total of 60 patients, aged 51 –89 years, were evaluated. Compared with patients given 150 mg twice a day, those given 110 mg twice a day were older (79 vs 67.5, p 75 years (p = 0.024) and was also affected by CrCl (CrCl
Publication date: Available online 24 May 2020Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Maira Jaqueline da Cunha, Katia Daniele Rech, Ana Paula Salazar, Aline Souza Pagnussat
ConclusionsThe e-ASPECTS software generates robust values for e-ASPECTS and acute infarct volumes when using ST ≤ 4 mm with ST = 1 mm yielding the best performance for predicting baseline stroke severity and clinical outcome after 90 days.Key Points•Clinical utility of automatically derived ASPECTS from computed tomography scans was shown in patients with acute ischemic stroke and treatment with mechanical thrombectomy.•Thin slices (= 1 mm) had the highest clinical utility in comparison with thicker slices (2–10 mm) by having the strongest correlation...
HIGH BLOOD PRESSURE may seem harmless but the condition can be a precursor to heart disease so it is important to keep it in check. Nuts have been shown to have a moderating effect on blood pressure and one nut comes out on top.
This study, for instance, attributes a patient’s waitlist/transplant outcome to the very last dialysis facility the patient was associated with. In epidemiology speak, this means the causal inference authors are trying to draw between for-profit status and good transplant outcomes is subject to time-varying confounding. As an example, if one is seeking an association between testosterone levels and risk of a heart attack, using the last testosterone level available would be a poor way of doing this study because testosterone levels are known to vary over time. The same applies to dialysis facilities. Patie...
Publication date: Available online 24 May 2020Source: Canadian Journal of CardiologyAuthor(s): Blake Sandery, Janis M. Dionne
CONCLUSION: As an easily accessible parameter, WBV might be a useful predictor of LVT formation within one year following acute anterior myocardial infarction. PMID: 32444531 [PubMed - as supplied by publisher]
Conditions: Stroke; Sleep-disordered Breathing; Sleep Apnea Syndromes; Sleep Apnea, Obstructive; Sleep Apnea, Central; Fragmentation, Sleep Intervention: Device: Treatment according to standard care recommandation Sponsor: University Hospital, Grenoble Not yet recruiting
Condition: Atrial Fibrillation Intervention: Procedure: Thoracoscopic Atrial fibrillation Ablation Sponsor: Nanjing Medical University Completed
Conditions: Stroke; Activities of Daily Living Interventions: Behavioral: Approach-Instrumental Activities of Daily Living; Behavioral: Home rehabilitation Sponsor: National Taipei University of Nursing and Health Sciences Recruiting
This study included 1962 patients who underwent transesophageal echocardiographic examination (TEE) prior to cardioversion or ablation in the years 2014-2018 in three cardiac centers. RESULTS: More than a quarter of AF patients had decreased eGFR (