Outcomes and Profiles of Older Patients Receiving Definitive Radiation Therapy for Muscle-Invasive Bladder Cancer at a Tertiary Medical Center

Publication date: Available online 26 February 2020Source: Practical Radiation OncologyAuthor(s): Kimberly R. Gergelis, Cole R. Kreofsky, Christopher S. Choo, Jason Viehman, W. Scott Harmsen, Scott C. Lester, Thomas M. Pisansky, Brian J. Davis, Bradley J. Stish, Richard Choo
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research

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Conclusions: Exclusive short course adjuvant VBT is an effective treatment in patients with early-stage endometrial cancer and provides good outcomes in terms of disease local control and DFS, with low rates of toxicity profile. PMID: 32395136 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Radiation-cystitis is an unavoidable side effect of external beam radiation therapy to the pelvis, even when delivered using normal tissue sparing delivery methods such as image guided radiation therapy (IGRT) and volumetric modulated arc therapy (VMAT). Cystitis symptoms include dysuria, urinary frequency, urgency, nocturia, the sensation of incomplete bladder voiding, haematuria and an increased risk of urinary tract infections. Acute radiation-cystitis develops during radiation therapy and generally resolves within weeks of completing radiation treatment.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
CONCLUSION: Cranberry capsules were not superior to beetroot-containing placebo capsules in managing radiation cystitis in our prostate patient cohort. RICAS may be a useful tool for measuring radiation cystitis in future studies. PMID: 32413530 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
Conclusions: In patients with prior TURP, prostate SBRT was well-tolerated. GU toxicity rates were comparable to similar patients treated with conventionally fractionated radiation therapy. Urinary quality of life was poor at baseline, but did not worsen clinically over time. Stricter dosimetric criteria could potentially improve the rate of high-grade late toxicity, but may increase the risk of peri-urethral recurrence.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Modern Pathology, Published online: 20 April 2020; doi:10.1038/s41379-020-0543-yIntegrated immunohistochemical and molecular analysis improves diagnosis of high-grade carcinoma in the urinary bladder of patients with prior radiation therapy for prostate cancer
Source: Modern Pathology - Category: Pathology Authors: Source Type: research
AbstractThe purpose of this study was to evaluate the efficacy of a 980-nm diode laser coagulation in women with radiation-induced hemorrhagic cystitis (RHC). We conducted a retrospective study of 21 RHC patients treated with a 980-nm diode laser between July 2014 and December 2017 at our institution. Data was collected with regard to age, sex, lower urinary tract symptoms, use of transfusions, a drop in hemoglobin levels, indication of radiotherapy, median time between radiation therapy and presentation, previous treatments, operative time, mean energy used, number of coagulated areas, catheterization time, discharge time...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
Radiation cystitis, a severely debilitating condition characterized by fibrosis, vascular damage, and compromised bladder function, develops in cancer survivors who received pelvic radiation treatment. This is the first study to compare the effects of radiation on the bladder across different murine genetic backgrounds, which may explain differences in patients ’ sensitivity to developing radiation cystitis after radiation cancer treatment. AbstractA subset of patients receiving radiation therapy for pelvic cancer develop radiation cystitis, a complication characterized by mucosal cell death, inflammation, hematuria,...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
AbstractTrimodality bladder preservation (BP) is an accepted alternative to radical cystectomy for patients with muscle invasive bladder cancer (MIBC). The global utilization of BP is variable, and practice patterns have not been previously studied in Russia. We sought to elucidate the contemporary BP practice patterns in Russia and determine the impact of the BP workshop on attitudes of Russian radiation oncologists (ROs) towards BP. The workshop was focused on patient workup, selection for BP, chemotherapy choices, radiation therapy (RT) contouring and planning, patient counseling. A total of 77 pre- and 32 matched post-...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
Radiation cystitis, a severely debilitating condition characterized by fibrosis, vascular damage, and compromised bladder function, develops in cancer survivors who received pelvic radiation treatment. This is the first study to compare the effects of radiation on the bladder across different murine genetic backgrounds, which may explain differences in patients ’ sensitivity to developing radiation cystitis after radiation cancer treatment. AbstractA subset of patients receiving radiation therapy for pelvic cancer develop radiation cystitis, a complication characterized by mucosal cell death, inflammation, hematuria,...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
We read the article “Second cancers in patients with locally advanced prostate cancer randomized to lifelong endocrine treatment with or without radical radiotherapy. Long term follow-up of the Scandinavian Prostate Cancer Group-7 trial” with great interest.1 The authors reported an increased incidence of bladder a nd lung cancers in patients who underwent 3-dimensional conformal radiation therapy. We appreciate the authors’ efforts to clarify the secondary cancer (SC) risk after radiation therapy (RT) for prostate cancer with a randomized controlled trial, although this was not the primary endpoint.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comments Source Type: research
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