Repolarized macrophages, induced by intermediate stereotactic dose radiotherapy and immune checkpoint  blockade, contribute to long-term survival in glioma-bearing mice

ConclusionsThese findings point to a novel immunologic mechanism underlying the interaction between radiotherapy and immunotherapy. They also provide the basis for clinical investigation of immunogenic dose radiation in combination with immune checkpoint blockade as a potential treatment approach for newly diagnosed high grade gliomas.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research