Aloe emodin inhibits telomerase activity in breast cancer cells: transcriptional and enzymological mechanism.
CONCLUSIONS: AE was a competitive inhibitor of telomerase and a G-quadruplex structure stabilizer. AE decreased the transcription of hTERT gene in the three breast cancer cell lines via up-regulation E2F1 and down-regulation c-myc expressions. The suppressed transcription was also related to the demethylation of the gene promoter.
PMID: 32207090 [PubMed - as supplied by publisher]
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Wang S, Yan WW, He M, Wei D, Long ZJ, Tao YM Tags: Pharmacol Rep Source Type: research
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