Desformylflustrabromine, a positive allosteric modulator of α4β2-containing nicotinic acetylcholine receptors, enhances cognition in rats.

CONCLUSIONS: These findings indicate that dFBr presents procognitive activity, supporting the strategy based on α4β2-nAChR potentiation as a plausible therapy for cognitive impairment.
PMID: 32207091 [PubMed - as supplied by publisher]

Source: Pharmacological Reports - March 22, 2020 Category: Drugs & Pharmacology Authors: Nikiforuk A, Litwa E, Krawczyk M, Popik P, Arias H Tags: Pharmacol Rep Source Type: research