Antagonizing miR-7 suppresses B cell hyperresponsiveness and inhibits lupus development.

CONCLUSION: The above data have demonstrated the critical roles of miR-7 not only in regulating PTEN expression and also B cell and Tfh cell function in lupus-prone MRLlpr/lpr lupus mice. Furthermore, the disease manifestations in MRLlpr/lpr lupus mice are efficiently improved by miR-7 antagomir, indicating miR-7 as a potential treatment strategy in SLE.
PMID: 32201226 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - March 18, 2020 Category: Allergy & Immunology Authors: Wang M, Chen H, Qiu J, Yang HX, Zhang CY, Fei YY, Zhao LD, Zhou JX, Wang L, Wu QJ, Zhou YZ, Zhang W, Zhang FC, Lipsky PE, Zhang X Tags: J Autoimmun Source Type: research