Development of a chimeric Fab directed against human galectin-3 and validation as an immune-PET tracer for the sensitive in vivo imaging of thyroid cancer.

CONCLUSIONS: The chimeric αGal3 89Zr-DFO-PAS200-Fab tracer has selective accumulation in the tumor-bearing thyroid lobe of xenograft mice. Thus, this novel radioactive probe offers potential to change thyroid cancer management, in addition to current, and to reduce unnecessary thyroidectomies. PMID: 32200708 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research