Thyroid V50 is a risk factor for hypothyroidism in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a retrospective study

We investigated the risk factors of radiation-induced thyroid dysfunction, then combined the clinical factors and optimum thyroid dosimetric parameters to predict the incidence rate of hypothyroidism (HT) and ...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research

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Publication date: May 2020Source: Journal of Comparative Pathology, Volume 177Author(s): L.M.C. Soares, A.H.B. Pereira, C.G. de Campos, L.S. Rocha, T.Á. dos Santos, M.A. Souza, P.C. Jark, C.A. Pescador
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Publication date: 5 August 2020Source: Journal of Pharmaceutical and Biomedical Analysis, Volume 187Author(s): Valentina Iacuzzi, Martina Zanchetta, Sara Gagno, Ariana Soledad Poetto, Marco Orleni, Elena Marangon, Michela Guardascione, Luisa Foltran, Bianca Posocco, Giuseppe Toffoli
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
The risk of radiation ‐related hypothyroidism (RHT) varied significantly depending on the dose‐volume parameters of thyroid radiation. We investigated and identified multiple thyroid dose‐volume thresholds for RHT in nasopharyngeal carcinomas treated with intensity‐modulated radiotherapy (RT), to guide risk strat ification of RHT and help in the design of individual RT plans. AbstractBackgroundTo identify thyroid dose ‐volume thresholds for radiotherapy (RT)‐related hypothyroidism (HT) in patients with nasopharyngeal carcinoma (NPC) treated with intensity‐modulated RT (IMRT). In this way, we desired to guide ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
The objective of the present study was to investigate the association between thyroid gland-dosimetric parameters and hypothyroidism induced by intensity-modulated radiotherapy in patients with nasopharyngeal carcinoma (NPC). A total of 52 patients with NPC treated in the Department of Radiation Oncology of The Affiliated Hospital of Xuzhou Medical University, from May 2008 to December 2016 were retrospectively enrolled in the present study and divided into two groups based on thyroid function: The euthyroid and hypothyroid groups. The association between hypothyroidism and clinical or dosimetric parameters were analyzed. ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
CONCLUSIONS: Despite the implementation of IMRT, survivors of NPC still experience many physical symptoms that affect long-term QoL many years after treatment. Depression, anxiety, and fatigue remain common in long-term survivors and are highly correlated with QoL. PMID: 30191868 [PubMed - in process]
Source: Health Physics - Category: Physics Authors: Tags: Int J Radiat Oncol Biol Phys Source Type: research
CONCLUSIONS: Axitinib achieved durable disease control with a favorable safety profile in heavily pretreated NPC patients. PMID: 29301831 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
CONCLUSION: The risk of hypothyroidism requiring thyroxin was significantly higher in NPC patients after RT than in the general Taiwanese population and HNC patients. Regular clinical and serum thyroid function tests are essential among NPC survivors after RT. PMID: 28532605 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
Hypothyroidism (HT) is one of the most common late side effects described in literature after radiation to the cervical region for malignancies including nasopharyngeal carcinoma (NPC) [1 –3]. The incidence of post-radiation HT varied in different reports, with most reported between 40% and 50% [4–15]. Half of the events occurred within 5years of follow up, with a peak incidence at 1–2years after radiation [4,6,7,9,13–17]. The major risk factors of HT identified included age [7,12,15,18], sex [2,9,10,12,18], the addition of chemotherapy [11,12], neck surgery [1–3,11,17], radiation dose [1,2,4,...
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
To  investigate the various clinical and thyroid dosimetric parameters that could predict the risk of primary hypothyroidism (HT) after intensity modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) and to determine useful thyroid dose constraints to guide radiation therapy planning.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
Primary hypothyroidism (HT) is a common occurrence after intensity modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC). This is a study to investigate the various clinical and thyroid dosimetric parameters that could predict the risk of primary hypothyroidism after IMRT and to determine useful thyroid dose constraints to guide radiotherapy planning. Thyroid V40 is predictive of primary hypothyroidism following intensity modulated radiotherapy for nasopharyngeal carcinoma and V40 ≤85% can be a useful dose constraint to adopt during IMRT planning without compromising tumor coverage.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
More News: Cancer & Oncology | Carcinoma | Hypothyroidism | Intensity-Modulated Radiation Therapy | Nasopharyngeal Cancer | Radiation Therapy | Study | Thyroid | Thyroid Cancer