Splice variant of growth hormone-releasing hormone receptor drives esophageal squamous cell carcinoma conferring a therapeutic target [Medical Sciences]

The extrahypothalamic growth hormone-releasing hormone (GHRH) and its cognate receptors (GHRH-Rs) and splice variants are expressed in a variety of cancers. It has been shown that the pituitary type of GHRH-R (pGHRH-R) mediates the inhibition of tumor growth induced by GHRH-R antagonists. However, GHRH-R antagonists can also suppress some cancers...

Source: Proceedings of the National Academy of Sciences - March 23, 2020 Category: Science Authors: Xiao Xiong, Xiurong Ke, Lu Wang, Zhimeng Yao, Yi Guo, Xianyang Zhang, Yuping Chen, Chi Pui Pang, Andrew V. Schally, Hao Zhang Tags: Biological Sciences Source Type: research