SOD2 promotes the expression of ABCC2 through lncRNA CLCA3p and improves the detoxification capability of liver cells.

This study elucidates the improvement of the detoxification of liver cells by a regulatory axis, SOD2-CLCA3P-IRF1-ABCC2, and provides novel insight into the modification of human liver cells that can be applied to bioartificial liver system or the study of SOD2 in drug metabolism. PMID: 32201199 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32201199?dopt=Abstract

Source: Toxicology Letters - March 18, 2020 Category: Toxicology Authors: Wang X, Li M, Peng L, Tang N Tags: Toxicol Lett Source Type: research