The Role of UC-MSC and Conditioned Medium in Inhibiting Impairment of Vision in Retinitis Pigmentosa
Condition: Retinitis Pigmentosa Interventions: Biological: Umbilical Cord Mesenchymal Stem Cell (UC-MSC); Biological: Conditioned Medium (CM) Sponsor: PT. Prodia Stem Cell Indonesia Completed
CONCLUSION: The demonstration of dyschromatopsia is very helpful in the diagnosis of inherited retinal diseases, in addition to modern imaging techniques, such as optical coherence tomography (OCT) and fundus fluorescence. New functional techniques enable quantification of color vision disturbances and could be useful as outcome parameters in clinical trials of new gene and stem cell-based therapies. PMID: 32458067 [PubMed - as supplied by publisher]
Publication date: Available online 30 April 2020Source: Stem Cell ResearchAuthor(s): Xiangchen Tang, Xingyu Liu, Zhigang Chen, Lixia Luo, Xialin Liu, Juan Deng, David Wan-Cheng Li, Yizhi Liu
Approximately one-third of non-syndromic retinal dystrophies involve a defect in a ciliary protein. Non-syndromic retinal ciliopathies include retinitis pigmentosa, cone dystrophy, cone-rod dystrophy, macular dystrophy, and Leber-congenital amaurosis (LCA). Many CEP290-LCA patients also exhibit auditory and olfactory defects. Induced pluripotent stem cells (iPS) cells were derived from patients with LCA and unaffected relatives. The National Eye Institute (NEI) seeks research collaborations and/or licensees for the use of these iPS cells.IC: NEINIH Ref. No.: E-100-2020Advantages: Extensive characteri...
CONCLUSIONS: Previous studies have described the role of LRRT in slowing down retinal degenerative diseases. Consequently, this surgical procedure could improve the clinical and rehabilitative prognostic parameters in RP patients. On the other hand, further clinical research and studies with longer follow-up will be needed to evaluate its efficacy. PMID: 32310198 [PubMed - as supplied by publisher]
Publication date: Available online 20 April 2020Source: Stem Cell ResearchAuthor(s): Yalan Zhou, Yutong Jing, Shengru Mao, Jian Liu, Zekai Cui, Yini Wang, Juan Chen, Hon fai Chan, Shibo Tang, Jiansu Chen
Publication date: April 2020Source: Stem Cell Research, Volume 44Author(s): Yalan Zhou, Chengcheng Ding, Shutao Xia, Yutong Jing, Shengru Mao, Jian Liu, Juan Chen, Hon fai Chan, Shibo Tang, Jiansu Chen
ABSTRACT Degenerative retinal diseases such as retinitis pigmentosa, Stargardt ’ s macular dystrophy, and age-related macular degeneration are characterized by irreversible loss of vision due to direct or indirect photoreceptor damage. No effective treatments exist, but stem cell studies have shown promising results. Our aim with this review was to describe the types of stem cells that are under study, their effects, and the main clinical trials involving them.RESUMO As doen ças degenerativas da retina, como retinose pigmentar, distrofia macular de Stargardt e degeneração macular relaciona &agrav...