The ICAReB Platform: A Human Biobank for the Institut Pasteur and Beyond

The ICAReB platform of Institut Pasteur provides access to human bio-resources for academic and private research teams worldwide, essentially in the fields of infection, immunity and neurosciences. More than 134,000 human quality controlled, duly annotated samples (mainly whole-blood derived products, but also stool, urine, saliva, swabs ….), from both healthy and diseased cohorts with open, regulated access, are available upon request. Both clinical investigation and biobanking activities are certified following ISO 9001:2015 and NF S96-900:2011 standards, respectively. ICAReB is a member of PIBnet (Pasteur International Biobanki ng network), BIOBANQUES and BBMRI, the French and pan-european biobanking networks, respectively. Funding statement: Funds come from IP (facilities and staff), and from various funding organisms or agencies (for specific projects):ANR (French National Research funding Agency):OH!Ticks project (see https://www.ohticks.fr/ 2017 –2020)AP/HP (Assistance Publique/H ôpitaux de Paris):MonaLisa (Multicentric Observational National Analysis on Listeriosis and Listeria) andListeriaGEN projects, 2009 –2022 and 2015–2024, respectivelyAVIESAN (French National alliance for Life Sciences and Health). Study of the innate immunity and the microbial flora during aplasia (PAMPA project, 2013 –2016)Bioaster (FrenchInvestissements d ’Avenir funding, Infectiology and Microbiology platform, Lyon-Paris, 2010 –2020)Biom ...
Source: Open Journal of Bioresources - Category: Biotechnology Source Type: research

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CONCLUSIONS: An approach to standardise current dose modification schemes in young children is proposed. The consented concept takes individual pharmacokinetic characteristics into account and involves adaptation of both the dose and the infusion duration potentially improving the safety of doxorubicin administration. PMID: 32466789 [PubMed - in process]
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Osborne H Abstract The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, γ-glutamyl peptides, polyamines, polycationic peptides, and protons. The CaSR plays a critical role in extracellular calcium (Ca2+ o) homeostasis, as demonstrated by the many naturally occurring mutations in the CaSR or its signaling partners that cause Ca2+ o homeostasis disorders. However, CaSR tissue expression in mammals is broad and includes tissues unrelated to Ca2+ o homeostasis, ...
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