Association of Oxidative Stress with Disease Activity and Damage in Systemic Lupus Erythematosus: A Cross Sectional Study from a Tertiary Care Centre in Southern India

AbstractTo study oxidative stress in systemic lupus erythematosus (SLE) by estimating serum oxidised LDL (OxLDL), 8-hydroxy-2 ′-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and total anti-oxidant status and to correlate with SLE disease activity and disease damage. Eighty SLE patients satisfying the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) 2012 criteria and 80 hea lthy controls were studied. Exclusion criteria were infections, renal insufficiency, other connective tissue diseases, drug-induced lupus, smoking, alcohol consumption. Disease activity was measured by SLE disease activity index-2 K (SLEDAI), disease damage was quantified by SLICC-Damage Index (SDI ). Sera was tested for OxLDL, 8-OHdG, and total antioxidant status (TAS) by double-antibody sandwich ELISA; MDA measured byColorimetric assay. Oxidative stress markers were compared between group1- controls, group 2-mildly active SLE (SLEDAI  ≤ 5), group 3- moderate to highly active SLE (SLEDAI ≥ 6). SLE patients had significantly higher MDA, 8-OHdG and lower TAS when compared to healthy controls, while OxLDL was similar in the three groups. MDA, 8-OHdG were significantly higher, TAS lower in group 3 compared to group 2. MDA had positive correlation with SLEDAI, TAS negatively correlated with SLEDAI. SLE with neuropsychiatric manifestations, vasculitis, anti-sdDNA antibodies had higher MDA, MDA/TAS ratio. SLE patients wi...
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research

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Publication date: Available online 3 June 2020Source: PolymerAuthor(s): Ahmed Gamal El-Shamy
Source: Polymer - Category: Chemistry Source Type: research
CONCLUSION: the findings have implications for the implementation of health promotion strategies among nursing students, in view of lifestyle changes. PMID: 32490956 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
CONCLUSION: BD on a single or multiple occasion during the month was associated with a higher prevalence of overweight. Therefore, such a lifestyle should be considered in weight gain prevention strategies. PMID: 32490946 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
This study will contribute in the development of cell culture in fermenter and synthesis of antioxidant secondary metabolites for commercial uses. PMID: 32490684 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
I've finished my AMCAS application and am ready to send it in...almost. I'm conflicted over whether or not I should write the disadvantaged student essay. To make a long story relatively short, my parents divorced when I was five, and my dad subsequently became absent from my life until 11th grade-ish. My mom developed alcoholism after the divorce and became very volatile (and incredibly abusive, but I'm not sure if I should mention that); she did not receive a formal education, and... Should I write the disadvantaged student essay?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Nontraditional Students Source Type: forums
Publication date: June 2020Source: Journal of the World Federation of Orthodontists, Volume 9, Issue 2Author(s): Vinod Krishnan
Source: Journal of the World Federation of Orthodontists - Category: Dentistry Source Type: research
CONCLUSION: These data suggest that uridine exhibits antioxidative properties which may mediate the protective effects of uridine in a neonatal rat model of hyperoxic brain injury. PMID: 32490647 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
CONCLUSIONS: PNH should be considered during differential diagnosis among patients with idiopathic PVT. Small PNH clones can be detected in PVT patients that we cannot clearly determine its relationship with PVT. We need furthermore studies to explore the potential role of this finding. PMID: 32490645 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Authors: Durhan A, Koşmaz K, Süleyman M, Tez M, Şenlikci A, Ersak C, Ünal Y, Pekcici MR, Karaahmet F, Şeneş M, Alkan Kuşabbi I, Eser EP, Hücümenoğlu S Abstract AIM: To investigate possible protective effects of Ankaferd Blood Stopper® (ABS) in an experimental liver IRI model. METHODS: The study was carried out on 30 female rats separated into 3 groups as sham, control (IRI), and treatment (IRI+ABS) groups. In IRI+ABS group, 0.5 ml/day ABS was given for 7 days before surgery. In IRI and IRI+ABS groups, hepatic pedicle was clamped for 30 minutes to apply ischemia. Then, after opening...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Authors: Pagani G, Zanchetta N, Galimberti L, Oreni L, Passerini S, Giacomelli A, Cordier L, Gismondo MR, Rizzardini G, Galli M, Antinori S Abstract Dengue Fever (DF), transmitted by Aedes mosquitoes, is the most common arthropod-borne infection, it is almost ubiquitous in tropical and subtropical areas with an estimate of 360 million infections per year. A competent vector (A. albopictus) is present in most of Southern Europe and is endemic in Italy. We conducted a 16-year retrospective study of probable/confirmed dengue fever observed at the Department of Infectious Diseases of Luigi Sacco Hospital in Milan, Ital...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
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