Discovery of dual cation- π inhibitors of acetylcholinesterase: design, synthesis and biological evaluation.

CONCLUSIONS: Compounds possessing methylidenecyclohexanone scaffolds, with characteristic dual-binding and involving strong cation-π interactions, serves as new leads for AChE and opens a new direction for drug discovery efforts.
PMID: 32200493 [PubMed - as supplied by publisher]

Source: Pharmacological Reports - March 20, 2020 Category: Drugs & Pharmacology Authors: Damuka N, Kammari K, Potshangbam AM, Rathore RS, Kondapi AK, Vindal V Tags: Pharmacol Rep Source Type: research