SPARCL: Atorvastatin Stroke Benefit Reinforced in New Analysis SPARCL: Atorvastatin Stroke Benefit Reinforced in New Analysis

A new analysis of the SPARCL trial has shown that the total number of vascular events prevented with atorvastatin was more than twice the number of first events prevented.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

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STATINS are a group of medicines that can help lower the level of cholesterol in the blood. Satins can also be taken to prevent heart disease, including heart attacks and strokes. Now, a new study has found that the cheap pills may also help treat ulcerative colitis.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionsPatients undergoing a coronary revascularization procedure who received moderate-intensity statins plus ezetimibe showed similar rates of major adverse cardiovascular events as patients who received high-intensity statins.
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
Br J Radiol. 2021 Sep 14:20210361. doi: 10.1259/bjr.20210361. Online ahead of print.ABSTRACTOBJECTIVES: Previous studies reported the association between inflammation and atrial fibrillation (AF). Pericoronary adipose tissue (PCAT) attenuation, PCATA, on cardiac CT angiography (CTA) reflects pericoronary inflammation. We hypothesized that the PCATA predicts AF recurrence after cryoballoon ablation (CBA) for paroxysmal and persistent AF.METHODS: We studied 364 patients (median age, 65 years) with persistent (n = 41) and paroxysmal (n = 323) AF undergoing successful first-session second-generation CBA with pre-ablation cardi...
Source: The British Journal of Radiology - Category: Radiology Authors: Source Type: research
In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Eur J Vasc Endovasc Surg. 2021 Sep 7:S1078-5884(21)00537-2. doi: 10.1016/j.ejvs.2021.06.031. Online ahead of print.ABSTRACTOBJECTIVE: The aims of this study were to assess the incidence of major vascular events (MVE) and peripheral vascular events (PVE) in people with a small asymptomatic abdominal aortic aneurysm (AAA) and model the theoretical benefits and costs of an intensified low density lipoprotein cholesterol (LDL-C) lowering programme.METHODS: A total of 583 participants with AAAs measuring 30 - 54 mm were included in this study. The control of LDL-C and prescription of lipid lowering drugs were assessed by dividi...
Source: PubMed: Eur J Vasc Endovasc ... - Category: Surgery Authors: Source Type: research
Recent studies of interventions initiated acutely following onset of minor ischemic stroke or transient ischemic attack (TIA) have disclosed early stroke recurrence rates that are substantially higher than long-term recurrence rates and that can be reduced by acute antiplatelet treatment interventions. These observations, bolstered by analysis based on kinetic modeling of the time course of recurrence following initial events, suggest that acute stroke patients experience an underlying vulnerable state that quickly transitions to a more stable state. Some evidence also supports the benefits of early treatment with direct-a...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
by Jack Bowden, Luke Pilling, Deniz T ürkmen, Chia-Ling Kuo, David Melzer In this paper we review the methodological underpinnings of the general pharmacogenetic approach for uncovering genetically-driven treatment effect heterogeneity. This typically utilises only individuals who are treated and relies on fairly strong baseline assumptions to estimate what we term the ‘genetically moderated treatment effect’ (GMTE). When these assumptions are seriously violated, we show that a robust but less efficient estimate of the GMTE that incorporates information on the population of untreated individuals can inste...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
IT IS estimated there are more than eight million people using statins in the UK. The drug is taken primarily to help manage high cholesterol levels, thereby warding off all associated complications; notably stroke and heart attack. Another side effect, however, could arise following use of the drug.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
STATINS are known to be effective at lowering cholesterol and protecting against heart attacks and strokes. However, scientists have recently advised to look out for some major side effects of statins that can cause pain and disruption to people's lives.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractPatients with genetically associated elevated lipoprotein(a) [Lp(a)] levels are at greater risk for coronary artery disease, heart attack, stroke, and peripheral arterial disease. To date, there are no US FDA-approved drug therapies that are designed to target Lp(a) with the goal of lowering the Lp(a) level in patients who have increased risk. The American College of Cardiology (ACC) has provided guidelines on how to use traditional lipid profiles to assess the risk of atherosclerotic cardiovascular disease (ASCVD); however, even with the emergence of statin add-on therapies such as ezetimibe and proprotein convert...
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
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