GSE85162 Transcriptional gender specific changes in the APP/PS1 mouse model of Alzheimer ’s disease pathology

Contributors : Tutu Oyelami ; An De Bondt ; Ilse Van den Wyngaert ; Kirsten Van Hoorde ; Ilse Dewachter ; John KempSeries Type : Expression profiling by arrayOrganism : Mus musculusThe prevalence of Alzheimer ’s disease is significantly higher in women than in men, with recent estimates suggesting that two thirds of AD patients are females. However, the reason for this is unclear and complex, with the fact that women live longer than men being a likely contributor to the observed disparity. Given the c omplexity of AD and the restrictions in studying any gender-linked biological differences in patients, an established alternative is to study animal models of a disease. To determine if there are gender differences in the response of animals to amyloid deposit, a key pathological feature of AD, we d id a genome-wide expression study on tissue obtained from the hippocampus and prefrontal cortex of male and female APP/PS1 mice at 8 months of age, a time at which significant cortical and hippocampal amyloid deposition is present. Amyloid deposit has previously been demonstrated in this model to be independent of gender. Regardless of the tissue sampled, we observed similar pathways affected in male and female mice. Focusing on major neurotransmitter and ionic pathways within the central nervous system reveal more profound gene expression changes in the prefrontal cortex and more restricted c hanges in the hippocampus. While the changes in the prefrontal cortex involved th...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research