Genes, Vol. 11, Pages 340: Functional Annotation and Curation of Hypothetical Proteins Present in A Newly Emerged Serotype 1c of Shigella flexneri: Emphasis on Selecting Targets for Virulence and Vaccine Design Studies

This study contributes to a better understanding of growth, survival, and disease mechanism at molecular level and provides potential new targets for designing drugs against Shigella infection.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research

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by Bakhos Jneid, Audrey Rouaix, C écile Féraudet-Tarisse, Stéphanie SimonSalmonella andShigella species are food- and water-borne pathogens that are responsible for enteric infections in both humans and animals and are still the major cause of morbidity and mortality in the emerging countries. The existence of multipleSalmonella andShigella serotypes as well as the emergence of strains resistant to antibiotics require the development of broadly protective therapies. Those bacteria utilize a Type III Secretion System (T3SS), necessary for their pathogenicity. The structural proteins composing the T3SS a...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
In this study, we have synthesized chimera of immunodominant regions of Intimin (eae) and IpaB (ipaB) designated as EI and expressed it in Lactococcus lactis (LL-EI) to develop a combinatorial oral vaccine candidate. Immune parameters and protective efficacy of orally administered LL-EI were assessed in the murine model. Significant EI-specific serum IgG, IgA, and fecal IgA antibody titer were observed in the LL-EI group. Considerable increase in EI-specific splenocyte proliferation and a concurrent upregulation of both Th1 and Th2 cytokines was observed in LL-EI immunized mice. Flow cytometry analysis also revealed a sign...
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.0c01595
Source: Journal of Physical Chemistry B - Category: Chemistry Authors: Source Type: research
Conditions:   Diarrhea;   Diarrhea Infectious Intervention:   Other: no intervention Sponsors:   Centre for Infectious Disease Research in Zambia;   European Vaccine Initiative;   Groupe de Recherche Action en Sante Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: May 2020Source: Molecular Immunology, Volume 121Author(s): Yrvin León, Lionel Zapata, Alexis Salas-Burgos, Angel Oñate
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 17 February 2020Source: International Journal of PharmaceuticsAuthor(s): Yadira Pastor, Isaiah Ting, Ana Luisa Martínez, Juan Manuel Irache, Carlos GamazoAbstractThermosensitive hydrogels have been studied as feasible needle-avoidance alternative to vaccine delivery. In this work, we report the development of a new thermal-sensitive hydrogel for intranasal vaccine delivery. This delivery system was formulated with a combination of the polymer Gantrez® AN119 and the surfactant Pluronic® F127 (PF127), with a high biocompatibility, biodegradability and immunoadjuvant propertie...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Abstract Vaccine implementation planning in low- and middle-income countries (LMIC) often focuses on children without considering special adult populations. We adapted an economic model developed by the United States Department of Defense (DoD) to evaluate the cost-effectiveness of vaccine acquisition strategies for Campylobacter-, ETEC-, Shigella-, and norovirus-associated gastroenteritis. We compared implementation costs with current medical management in the Peruvian armed forces, a special population of low- and middle-income (LMIC) adults with a high incidence of infectious gastroenteritis. Pathogen-specific ...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Conditions:   Immunisation;   Shigella Infection Interventions:   Other: Placebo;   Biological: Shigella sonnei strain 53G;   Biological: WRSs2 Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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