New ISHLT nomenclature & diagnostic criteria: Antibody-mediated rejection in heart transplantation

(Elsevier Health Sciences) Antibody-mediated rejection of the transplanted heart is a recognized clinical complication and a major limitation to survival of patients who have undergone heart transplantation. Experts have now developed a new working formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection. Their consensus statement is published in the Dec. issue of The Journal of Heart and Lung Transplantation and is freely available online.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Frailty is common in adults with end-stage lung disease and is associated with death before and after lung transplantation. We aimed to determine whether frailty changes from before to after lung transplant.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
END-STAGE HEART FAILURE (HF) results from a myriad of etiologies and represents a major financial and healthcare burden.1 Since 1983, nearly 150,000 pediatric and adult heart transplants have been reported to the International Society for Heart and Lung Transplantation (ISHLT) Registry, with medical advancements in perioperative care resulting in improved patient outcomes over time.2 This paper aims to assess outcomes within the field of heart transplantation. The authors will focus on historical context, current demographics, indications, and contraindications for transplantation.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Expert Review Source Type: research
Right-sided heart failure develops in lung transplantation candidates on prolonged peripheral extracorporeal membrane oxygenation support and is a major determinant of mortality. The use of central venoarterial extracorporeal membrane oxygenation for bridging of right-sided heart failure to lung transplantation was evaluated.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We have applied cutting-edge mass cytometry (MC) technology to serial bronchoalveolar lavage (BAL) cells obtained from lung transplant recipients (LTRs) and have used it to compare the cellular composition of the BAL compartment in patients who remain stable or go on to develop lung allograft dysfunction (LAD), defined here as a drop, from any cause, in the forced expiratory volume in 1 second of 20% from the best post-transplant baseline value.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 17 Source Type: research
We examined the ratio of regulatory T cells (Tregs, which express Foxp3) to T effector cells (Teff) in TBBx as a predictor of outcome.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 16 Source Type: research
Long-term survival after lung transplantation (LTx) is hampered by chronic lung allograft dysfunction, with bronchiolitis obliterans syndrome (BOS) as its most common phenotype. Bronchiectasis (BRECT), hyperinflation and airtrapping are considered the key features of BOS on chest CT. We investigated whether chest CT and key features have prognostic value at BOS diagnosis in patients with established BOS after LTx.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 15 Source Type: research
Chronic Allograft Dysfunction (CLAD) with Bronchiolitis obliterans (BOS) phenotype is a major limitation for long term survival after lung transplantation (LT). Predictive biomarkers for BOS are unavailable. Purpose of our study was to establish a tractable system to evaluate the effects of pre-transplant antibodies to self-antigens (AutoAbs) and to examine specific patterns that correlate with BOS.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 14 Source Type: research
Chronic lung allograft dysfunction (CLAD) is a clinical/functional diagnosis that cannot be defined by histology in transbronchial biopsies (TBBs). Moreover, understanding the biology of CLAD is crucial for prevention and potential treatment. We studied gene expression associated with CLAD in TBBs, but also studied mucosal biopsies from the third bronchial bifurcation (3BMBs).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 13 Source Type: research
The DLCO measures the capacity of the lungs to exchange gas across the alveolar-capillary interface. We hypothesized that DLCO is a sensitive measure of injurious allograft processes that can disrupt this interface. Our goals were to describe the trajectory of DLCO measurements after lung transplantation, and to determine the prognostic significance of DLCO on chronic lung allograft dysfunction (CLAD) and survival.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 12 Source Type: research
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