Immunological outcomes in infants with ROP after dexamethasone and aminophylline.

Immunological outcomes in infants with ROP after dexamethasone and aminophylline. Clin Exp Pharmacol Physiol. 2020 Mar 21;: Authors: Balashova L, Bykovskaya S, Korobova L, Kuznetsova Y, Kantardgy E, Mukhin V, Popov A Abstract This research aims to improve anaesthesia services given to preterm infants by the use of dexamethasone and aminophylline administrated under sevoflurane, and to analyze its effect on the cell-mediated immunity (CD4+CD25+Foxp3+(Treg) and CD4+CD25highFoxp3+CD127low). We have examined 74 premature babies with retinopathy of prematurity (ROP) at the 3-5 stages during the 25-32 gestation period (1-6 months after birth). Both immunomodulators had not significant effect on clinical parameters after one dose (p>0.05). Aminophylline (2.4% solution, 0.1 ml/kg or 0.132 ml per infant on average) and dexamethasone (0.4% solution, 0.1 mg/kg or 0.132 ml per infant on average) were intravenously injected 15 minutes before the end of the surgery. Required anaesthesia depth was maintained with inhalation anesthetic (1.5-2.0 IAC) and the minimum fresh gas flow was not less than 2 liters. Blood samples were taken from the vein (anesthesia induction stage) into the tubes containing EDTA (the anticoagulant), stored at 20-25° C, and then, processed and stained within 24 hours after sampling. Both immunomodulators had not significant effect on clinical parameters after one dose (p>0.05). Short-term shift in regulatory T cell level affected by de...
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research

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CONCLUSION: Physicians should acknowledge and prepare for common possible adverse events at the stage of pregnancy after non-obstetric surgery, and effort to shorten the duration of surgery and anesthesia is needed. PMID: 32329258 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Conclusions and Relevance Electroconvulsive therapy is a highly effective and safe treatment modality for unipolar depression, bipolar disorder, schizophrenia, and other psychiatric illnesses. Electroconvulsive therapy treatment in pregnancy requires a multidisciplinary team approach with obstetrics, maternal-fetal medicine, psychiatry, and anesthesiology, but is overall felt to be safe and effective. Target Audience Obstetricians and gynecologist, family medicine physicians. Learning Objectives After completing this activity, the learner should be better able to assess the current evidence and best practices regar...
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: CME ARTICLES Source Type: research
This study investigates the influence of maternal age on birth procedure, gestational age, and rate of interventions during delivery. The influence of maternal parity is also analyzed. Material and Methods Data from the Austrian Register of Births was retrospectively collected and evaluated. The collected data was the data of all singleton live births in Austria between January 1, 2008 and December 31, 2016 (n = 686 272). Multiple births and stillbirths were excluded from the study. Maternal age and parity were analyzed in relation to predefined variables (birth procedure, gestational age, episiotomy in cas...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
ConclusionSurgical indications for pituitary tumors are rare during pregnancy; therefore, surgery should be avoided when possible. Further, the second trimester should be considered as the optimal surgical period. Severe visual disturbance and uncontrolled CD are the main surgical indications during pregnancy.
Source: Pituitary - Category: Endocrinology Source Type: research
We ’ ve come a long way from the days when surgeons were taught that infants ’ nervous systems were too undeveloped to feel pain.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Children and Childhood Pain-Relieving Drugs Babies and Infants Premature Babies Surgery and Surgeons Parenting Hospitals Anesthesia and Anesthetics Source Type: news
ConclusionsPeribulbar block was a safe anesthetic technique in our sample considered.ResumoJustificativa e objetivosAté o momento não há um consenso sobre a técnica anestésica mais adequada para o tratamento de retinopatia da prematuridade. O bloqueio peribulbar pode reduzir a incidência de reflexo oculocardíaco e apneia no pós-operatório. O objetivo deste estudo foi relatar os resultados do bloqueio peribulbar, quando combinado com anestesia geral, para o tratamento a laser de retinopatia da prematuridade em bebês prematuros.MétodosUma análi...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Thrombosis is said to be the new epidemics of neonatal intensive care wards - one of the most high-powered health care facilities of the 21st century. Small diameter vessels, immature hemostasis, congenital diseases and cardiovascular shunts like PDA and PFO contribute to the high risk of thromboembolic events. Owing to decreasing perinatal mortality, the number of neonatal patients increases – 1 in 10 children is born premature, with a total number of 15 million premature births worldwide [1]. Vascular cannulation of the neonates is challenging, though neonates have an exceptional afterbirth access route – cat...
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research
Purpose of review To put in perspective, the various challenges that faces pediatric anesthesiologists because of the recently lowered limits with regards to the viability of a fetus. Both medical and ethical considerations will be highlighted. Recent findings Issues related to: who should anesthetize these tiny babies; can we provide adequate and legal monitoring during the anesthetic; does these immature babies need hypnosis and amnesia and the moral/ethical implications associated with being involved with care of doubtful long-term outcome are reviewed. Summary There does currently not exist sufficient research ...
Source: Current Opinion in Anaesthesiology - Category: Anesthesiology Tags: PEDIATRIC ANESTHESIA: Edited by Tom G. Hansen Source Type: research
CONCLUSION: In our infant lung model, a shorter tube resulted in a lower work of breathing and lower ventilator-generated peak inspiratory pressure. PMID: 29633434 [PubMed - as supplied by publisher]
Source: Paediatric Anaesthesia - Category: Anesthesiology Authors: Tags: Paediatr Anaesth Source Type: research
This article gives a comprehensive review of the anatomical and physiological differences between the adult and the pediatric population and the anaesthetic implications of the various neurosurgical disorders.
Source: Journal of Pediatric Neurosciences - Category: Neuroscience Authors: Source Type: research
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