Immunological outcomes in infants with ROP after dexamethasone and aminophylline.

Immunological outcomes in infants with ROP after dexamethasone and aminophylline. Clin Exp Pharmacol Physiol. 2020 Mar 21;: Authors: Balashova L, Bykovskaya S, Korobova L, Kuznetsova Y, Kantardgy E, Mukhin V, Popov A Abstract This research aims to improve anaesthesia services given to preterm infants by the use of dexamethasone and aminophylline administrated under sevoflurane, and to analyze its effect on the cell-mediated immunity (CD4+CD25+Foxp3+(Treg) and CD4+CD25highFoxp3+CD127low). We have examined 74 premature babies with retinopathy of prematurity (ROP) at the 3-5 stages during the 25-32 gestation period (1-6 months after birth). Both immunomodulators had not significant effect on clinical parameters after one dose (p>0.05). Aminophylline (2.4% solution, 0.1 ml/kg or 0.132 ml per infant on average) and dexamethasone (0.4% solution, 0.1 mg/kg or 0.132 ml per infant on average) were intravenously injected 15 minutes before the end of the surgery. Required anaesthesia depth was maintained with inhalation anesthetic (1.5-2.0 IAC) and the minimum fresh gas flow was not less than 2 liters. Blood samples were taken from the vein (anesthesia induction stage) into the tubes containing EDTA (the anticoagulant), stored at 20-25° C, and then, processed and stained within 24 hours after sampling. Both immunomodulators had not significant effect on clinical parameters after one dose (p>0.05). Short-term shift in regulatory T cell le...
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research