How to reduce lung cancer mortality among people living with HIV?

[How to reduce lung cancer mortality among people living with HIV?] Rev Mal Respir. 2020 Mar 17;: Authors: Ruppert AM, Lavolé A, Makinson A, Le Maître B, Cadranel J Abstract Lung cancer is the leading cause of cancer related death among people living with HIV (PLHIV). Tobacco exposure is higher among PLHIV (38.5%) and mainly explains the increased risk of lung cancer. To reduce lung cancer mortality, two approaches need to be implemented: lung cancer screening with low-dose thoracic CT scan and smoking cessation. Low dose CT scan is feasible in PLHIV. The false positive rate is not higher than in the general population, except for cases with CD4
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

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Combination of Fluorine-18 Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography (¹⁸F-FDG PET/CT) and Tumor Markers to Diagnose Lymph Node Metastasis in Non-Small Cell Lung Cancer (NSCLC): A Retrospective and Prospective Study. Med Sci Monit. 2020 Jun 02;26:e922675 Authors: Zhai X, Guo Y, Qian X Abstract BACKGROUND The early diagnosis of lymph node (LN) metastasis is crucial for patients with non-small cell lung cancer (NSCLC). However, the diagnosis of LN metastasis mainly dependent on ¹⁸F-FDG PET/CT (fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomo...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Nature Reviews Clinical Oncology, Published online: 26 May 2020; doi:10.1038/s41571-020-0393-zLung cancer screening is currently based only on low-dose CT scans; however, novel, more accessible methods that might improve uptake and adherence are eagerly awaited. New liquid biopsy approaches promise to revolutionize cancer screening. Herein, we discuss the opportunities and challenges associated with two such novel assays.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research
This study explored patient experience of MR treatment planning scans in addition to a CT scan.
Source: Radiography - Category: Radiology Authors: Source Type: research
ConclusionsTreatment of patients with relapsed solid tumors with 7.5  mg/d E and 800 mg/d S is safe and feasible. Early metabolic response in FDG‐PET was not confirmed in CT scan several weeks later. The combination of S and E is obviously not sufficient to induce durable responses in patients with KRAS‐mutant solid tumors.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Conclusion: Anti-GABA-B receptor encephalitis mainly occurred in middle-aged and elderly men, and the disease onset was relatively sudden. Before disease onset, some patients experienced fever and non-specific respiratory symptoms, which mainly manifested as frequent epileptic seizures, cognitive dysfunction, and abnormal mental behavior. MRI and PET-CT revealed abnormal signals and local metabolism, respectively, in the temporal lobe. Moreover, the disease has a close relationship with lung cancer, which requires long-term follow-up observation.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Condition:   Lung Cancer Intervention:   Device: PET/CT Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Weekly docetaxel and platinum-based drug doublet combined with TR yielded promising results in stage III NSCLC, with high survival rates. The toxicity of this association is acceptable, with mainly manageable esophagitis. These findings warrant validation in a prospective study before considering this association for standard of care. PMID: 32439358 [PubMed - as supplied by publisher]
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
Abstract BACKGROUND: Adherence to annual low-dose computed tomography was 95% in the National Lung Screening Trial and must be replicated in order to achieve mortality benefit from screening. RESEARCH QUESTION: Determine adherence rates within the Veterans Affairs Lung Cancer Screening Demonstration Project (LCSDP) and identify factors predictive of adherence. STUDY DESIGN: and Methods: A secondary data analysis of the LCSDP conducted at 8 VA medical centers was performed to determine adherence to follow-up imaging and determine factors predictive of adherence. RESULTS: A total of 2103 patients were...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
240Purpose: Reliable predictive and prognostic markers are still lacking for patients treated with immunotherapy for non-small cell lung cancer (NSCLC). The purpose of this study was to investigate the prognostic and predictive values of different baseline metabolic parameters, including whole-body metabolic tumor volume (wMTV), from 18F-FDG PET/CT scans in patients with NSCLC treated with immunotherapy. Methods: Maximum and peak standardized uptake values, wMTV and total lesion glycolysis (wTLG) as well as clinical and biological parameters, were recorded in 75 prospectively included patients with NSCLC treated with immun...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer I Source Type: research
242Introduction: Immune checkpoint inhibitors (IOs) have a different mechanism of action as compare to cytotoxic drugs by reactivating adaptive immune system. This unique mechanism poses a challenge to evaluate response to therapy by computed tomography (CT). We herewith compare the immune response evaluation criteria in solid tumors (iRECIST) to immune adaptive positron emission tomography response criteria in solid tumors (imPERCIST) in non small cell lung carcinoma (NSCLC) patients treated with nivolumab. Methods: 20 patients of metastatic NSCLC underwent 18F-FDG PET/CT scan prior to initiation (PET 0), after 4 cycles (...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer I Source Type: research
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