Effects of carbamazepine, eslicarbazepine, valproic acid and levetiracetam on bone microarchitecture in rats.
CONCLUSIONS: Our findings suggest that VPA affects the microarchitectural properties of the bone. The AEDs CBZ, ESL and LEV appear to have less adverse effects on bone biology and may be a better choice when treating patients with respect to bone health. PMID: 32193854 [PubMed - as supplied by publisher]
Publication date: Available online 15 July 2020Source: Journal of Chemical NeuroanatomyAuthor(s): Somayeh Vazifehkhah, Ali Mohammad Khanizadeh, Tourandokht Balouchnejad Mojarad, Farnaz Nikbakht
CONCLUSION: MiR-181b suppressed the progression of epilepsy via regulation of RASSF1A and lncRNA ZNF883. Thus, miR-181b might serve as a new target for treatment of EP. PMID: 32655808 [PubMed]
CONCLUSIONS: Stigma burden can be substantial among PLWE and may vary depending on contextual factors such as mental health comorbidity. Care approaches that screen for psychiatric comorbidities, address low health literacy, institute promising self-management programs, and employ effective health communication strategies about epilepsy misconceptions, may reduce epilepsy related burden. PMID: 32657063 [PubMed]
This article is the first in a series on AED treatments for epilepsy in South Korea. PMID: 32657058 [PubMed]
Publication date: Available online 14 July 2020Source: Epilepsy &BehaviorAuthor(s): Amal Alkhotani, Muhammad I. Siddiqui, Fahad Almuntashri, Renad Baothman
Abstract PURPOSE OF REVIEW: The discovery of new disease-causing genes and availability of next-generation sequencing platforms have both progressed rapidly over the last few years. For the practicing neurologist, this presents an increasingly bewildering array both of potential diagnoses and of means to investigate them. We review the latest newly described genetic conditions associated with dystonia, and also address how the changing landscape of gene discovery and genetic testing can best be approached, from both a research and a clinical perspective. RECENT FINDINGS: Several new genetic causes for disorde...
Abstract PURPOSE OF REVIEW: Hybrid PET- MRI is a technique that has the ability to improve diagnostic accuracy in many applications, whereas PET and MRI performed separately often fail to provide accurate responses to clinical questions. Here, we review recent studies and current developments in PET-MRI, focusing on clinical applications. RECENT FINDINGS: The combination of PET and MRI imaging methods aims at increasing the potential of each individual modality. Combined methods of image reconstruction and correction of PET-MRI attenuation are being developed, and a number of applications are being introduced...
During the outbreak of coronavirus disease 2019 (COVID-19) clinicians are increasingly involved in the observation of possible neurological complications due to the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) . Among neurologic emergencies, new onset seizures and status epilepticus in non-epileptic patients are up to now, infrequently reported .
Background: Based on previous studies, vitamin D deficiency could lead to nerve stimulation. The purpose of the present study was to determine frequency and duration of seizures in children with idiopathic epilepsy in two groups; normal level of vitamin D versus decreased level of vitamin D. Methods: This pilot, comparative study was carried out in Zanjan University of Medical Sciences on total 40 children aging between 2 to 12 years old (23 male and 17 female) with the diagnosis of idiopathic epilepsy. All patients were receiving anti-epileptic drugs. The initial questionnaire was completed by each parent. Total 40 epilep...
Publication date: Available online 14 July 2020Source: SeizureAuthor(s): Massimiliano Beghi, Le Zhang, Ettore Beghi, Giorgia Giussani, Giuseppe Erba, Elisa Longinetti, Brian M. D'Onofrio, Elisa Bianchi, Fang Fang, Torbjorn Tomson, Zheng Chang