Cancers, Vol. 12, Pages 749: Non-Coding microRNAs as Novel Potential Tumor Markers in Testicular Cancer

Cancers, Vol. 12, Pages 749: Non-Coding microRNAs as Novel Potential Tumor Markers in Testicular Cancer Cancers doi: 10.3390/cancers12030749 Authors: Manuel Regouc Gazanfer Belge Anja Lorch Klaus-Peter Dieckmann Martin Pichler Testicular cancer is an important disease with increasing incidence and a high burden of morbidity and mortality in young men worldwide. Histological examination of the testicular tissue after orchiectomy plays an important role alongside patient history, imaging, clinical presentation and laboratory parameters. Surgical procedures and chemotherapeutic treatment provide a high chance of cure in early stages, though some patients in advanced stages belonging to a poor risk group experience cancer-related death. Though conventional serum-based tumor markers, including α-fetoprotein (AFP), the β-subunit of human chorionic gonadotropin (β-hCG), and lactate dehydrogenase (LDH), are useful as prognostic and diagnostic biomarkers, unfortunately, these tumor markers only have a sensitivity of about 60%, and in pure seminoma even lower with about 20%. Therefore, the development of new tumor markers is an important and intensively ongoing issue. The analysis of epigenetic modification and non-coding RNA microRNAs (miRNAs) are carrying most promising potential as tumor markers in future. miRNAs are small RNAs secreted by testicular tumor cells and circulate and be measurable in body fluids. In recent years, m...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research