Exendin-4 Ameliorates Cardiac Remodeling in Experimentally Induced Myocardial Infarction in Rats by Inhibiting PARP1/NF- κB Axis in A SIRT1-Dependent Mechanism.
In conclusion, exendin-4 is a potent cardioprotective agent that prevents post-MI inflammation and cardiac remodeling by activating SIRT1-induced inhibition of PARP1.
PMID: 32193876 [PubMed - as supplied by publisher]
Source: Cardiovascular Toxicology - Category: Cardiology Authors: Eid RA, Alharbi SA, El-Kott AF, Eleawa SM, Zaki MSA, El-Sayed F, Eldeen MA, Aldera H, Al-Shudiefat AAS Tags: Cardiovasc Toxicol Source Type: research