Exendin-4 Ameliorates Cardiac Remodeling in Experimentally Induced Myocardial Infarction in Rats by Inhibiting PARP1/NF- κB Axis in A SIRT1-Dependent Mechanism.

In conclusion, exendin-4 is a potent cardioprotective agent that prevents post-MI inflammation and cardiac remodeling by activating SIRT1-induced inhibition of PARP1. PMID: 32193876 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32193876?dopt=Abstract

Source: Cardiovascular Toxicology - March 18, 2020 Category: Cardiology Authors: Eid RA, Alharbi SA, El-Kott AF, Eleawa SM, Zaki MSA, El-Sayed F, Eldeen MA, Aldera H, Al-Shudiefat AAS Tags: Cardiovasc Toxicol Source Type: research