Sacubitril/Valsartan Therapy Ameliorates Ventricular Tachyarrhythmias Inducibility in a Rabbit Myocardial Infarction Model

Coronary artery disease (CAD) is the most common cause of heart failure (HF) in developed countries. Ventricular tachycardia (VT)/ventricular fibrillation (VF) are the most frequent causes of sudden cardiac death (SCD) in patients with post-myocardial infarction (MI) HF. Pharmacological therapies have been shown to reduce mortality in these patient, and most of those medications involve the sympathetic nervous system and the renin-angiotensin-aldosterone pathway, such as beta blockers, angiotensin-converting-enzyme inhibitors (ACEis), angiotensin II receptor blockers (ARBs) and aldosterone antagonists.

Source: Journal of Cardiac Failure - March 20, 2020 Category: Cardiology Authors: Po-Cheng Chang, Hung-Ta Wo, Hui-Ling Lee, Shien-Fong Lin, Yen Chu, Ming-Shien Wen, Chung-Chuan Chou Source Type: research