The role of HLA-DP mismatches and donor specific HLA-DP antibodies in kidney transplantation: A case series.

CONCLUSIONS: Isolated HLA-DP DSA are rare, yet constitute a significant risk for AMR. We identified high-risk eplet mismatches that can lead to HLA-DP DSA formation. We therefore recommend HLA-DP typing to perform HLA-DP DSA analysis before transplantation. HLA-DP DSA with high MFI were not always correlated with positive crossmatch results. PMID: 32194154 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32194154?dopt=Abstract

Source: Transplant Immunology - March 15, 2020 Category: Transplant Surgery Authors: Daniëls L, Claas FHJ, Kramer CSM, Senev A, Vanden Driessche M, Emonds MP, Van Laecke S, Hellemans R, Abramowicz D, Naesens M Tags: Transpl Immunol Source Type: research