An update on disease biomarkers for Hodgkin lymphoma.

An update on disease biomarkers for Hodgkin lymphoma. Expert Rev Hematol. 2020 Mar 20;: Authors: Cirillo M, Borchmann S Abstract Introduction: Hodgkin Lymphoma (HL) carries an overall excellent prognosis for young patients treated with multimodal therapy. Predicting an individual patient's prognosis is currently heavily dependent on imaging modalities such as Positron Emission Tomography (PET).Areas covered: Potential biomarkers from serum, tissue, circulating nucleic acids and non-tumour derived cells have all been reported to be of prognostic relevance in HL. We review a range of these biomarkers and discuss the integration of new biomarkers into individualised patient care.Expert opinion: Better prognostic markers are needed to predict an individuals response to HL therapy. Interim PET-scan improves the ability to predict long-term treatment responders. However, it is our opinion that supplementation of PET results with additional biomarkers (including circulating tumour DNA, protein biomarkers, tissue genotyping and metabolic tumour volume) are likely to improve risk stratification for future patients with HL. PMID: 32193957 [PubMed - as supplied by publisher]
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research