Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk.

Conclusions DLG1 joins a growing list of genes encoding ion channel interacting proteins (ChIPs) identified as potential channelopathy-susceptibility genes because of their ability to regulate the trafficking, targeting, and modulation of ion channels that are critical for the generation and propagation of the cardiac electrical impulse. Dysfunction in these critical components of cardiac excitability can result potentially in fatal cardiac disease. PMID: 32196358 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32196358?dopt=Abstract

Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2020 Category: Physiology Authors: Musa H, Marcou CA, Herron TJ, Makara M, Tester DJ, O'Connell R, Rosinski B, Guerrero-Serna G, Milstein ML, Monteiro Da Rocha A, Ye D, Crotti L, Nesterenko VV, Castelletti S, Torchio M, Kotta MC, Dagradi F, Antzelevitch C, Mohler PJ, Schwartz PJ, Ackerman Tags: Am J Physiol Heart Circ Physiol Source Type: research