Low molecular weight heparin promotes transcription and release of placental growth factor from endothelial cells.
CONCLUSIONS: LMWH exposure promotes the release of PlGF from endothelial cells through the upregulation of PlGF-1 mRNA expression. Stimulation of circulating PlGF levels by LMWH may be an important mechanism by which LMWH could reduce the risk of preeclampsia, or minimize disease severity.
PMID: 32196359 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: McLaughlin K, Nadeem L, Wat J, Baczyk D, Lye SJ, Kingdom J Tags: Am J Physiol Heart Circ Physiol Source Type: research