Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis.

Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis. Chronobiol Int. 2020 Mar 20;:1-11 Authors: Butler MP, Thosar SS, Smales C, DeYoung PN, Wu H, Hussain MV, Morimoto M, Hu K, Scheer FAJL, Shea SA Abstract Obstructive sleep apnea (OSA) is associated with hypertension, cardiovascular disease, and a change in the 24 h pattern of adverse cardiovascular events and mortality. Adverse cardiovascular events occur more frequently in the middle of the night in people with OSA, earlier than the morning prevalence of these events in the general population. It is unknown if these changes are associated with a change in the underlying circadian rhythms, independent of behaviors such as sleep, physical activity, and meal intake. In this exploratory analysis, we studied the endogenous circadian rhythms of blood pressure, heart rate, melatonin and cortisol in 11 participants (48 ± 4 years; seven with OSA) throughout a 5 day study that was originally designed to examine circadian characteristics of obstructive apnea events. After a baseline night, participants completed 10 recurring 5 h 20 min behavioral cycles divided evenly into standardized sleep and wake periods. Blood pressure and heart rate were recorded in a relaxed semirecumbent posture 15 minutes after each scheduled wake time. Salivary melatonin and cortisol concentrations were measured at 1-1.5...
Source: Chronobiology International - Category: Biology Authors: Tags: Chronobiol Int Source Type: research

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An 81-year-old man presented to the clinic for an annual general medical examination with insomnia and pruritus. His insomnia was associated with nocturnal leg restlessness, foot cramping, and pruritus of his feet. His cramping was not associated with activity and occurred mostly at night. He reported no fevers, weight loss, night sweats, numbness, skin lesions, or purulence. His medical history included obstructive sleep apnea (OSA) treated with continuous positive airway pressure therapy, hypertension, hyperlipidemia, gastroesophageal reflux disease, bilateral chronic onychomycosis of the toenails (recently completed tre...
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Residents ’ Clinic Source Type: research
CONCLUSION: Even though CIH did not cause abnormal pulmonary function or PH, early lung injury was detected at the molecular level in rats exposed to CIH. Treatment with Ad ameliorated the pulmonary injury by activating the SIRT3/SOD2 pathway, reducing ROS generation, and inhibiting ROS-associated lung cell apoptosis. PMID: 32458376 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
AbstractBackgroundObstructive sleep apnea syndrome (OSAS) is associated with a variety of systemic diseases. Among patients with chronic kidney diseases (CKD), the prevalence of OSAS is high. OSAS can induce progression of CKD. However, whether or not OSAS can cause renal damage in healthy people is not clear. Thus, the purpose of this meta-analysis was to elucidate whether or not there was an association between OSAS and early renal damage.MethodsPubMed, Embase Database, Cochrane Library, Web of Science, China National Knowledge Infrastructure, China Biology Medicine Database, Chinese Scientific Journals Database, and Wan...
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Abstract BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is associated with a variety of systemic diseases. Among patients with chronic kidney diseases (CKD), the prevalence of OSAS is high. OSAS can induce progression of CKD. However, whether or not OSAS can cause renal damage in healthy people is not clear. Thus, the purpose of this meta-analysis was to elucidate whether or not there was an association between OSAS and early renal damage. METHODS: PubMed, Embase Database, Cochrane Library, Web of Science, China National Knowledge Infrastructure, China Biology Medicine Database, Chinese Scientific Journa...
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
Abstract Although excessive daytime sleepiness is commonly evaluated in clinical and research settings using the Epworth Sleepiness Scale, few studies have assessed the factors associated with its incidence in the general population. We prospectively investigated the predictors of incident and persistent excessive daytime sleepiness in 2,751 subjects (46.1% men, mean age 56.0 ± 9.8 years) from the CoLaus-PsyCoLaus population-based cohort (Lausanne, Switzerland) over 5 years. Participants completed the Epworth Sleepiness Scale and the Pittsburgh Sleep Quality Index, and underwent a full c...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
ConclusionSmall artery disease is the most common stroke subtype associated with obstructive sleep apnea. Clinicians must vigilantly assess the presence of obstructive sleep apnea in ischemic stroke patients, especially in patients whose stroke is attributed to small artery disease.
Source: Neurological Sciences - Category: Neurology Source Type: research
This study aims to determine if SCZ patients are at increased risk of incident OSA.MethodsA total of 5092 newly diagnosed SCZ patients and 5092 non-SCZ controls matched by gender, age, and index year were included between 2000 and 2012 and followed to 2013. Participants newly diagnosed with OSA were defined as incidents. Cox regression analysis was used to calculate the hazard ratio (HR) with 95% confidence intervals (CI) of the OSA incidence rate between the two groups studied.ResultsSCZ patients were at increased risk of OSA compared to non-SCZ controls after adjusting for gender, age, comorbidities, and duration of anti...
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
Atrial fibrillation (AF) is known to be one of the most common rhythm disorders encountered in clinical practice. Yet, AF only rarely occurs as a solitary diagnosis. On the contrary, AF typically is predisposed to be numerous factors. The most important predisposing factor for AF is age, with both AF incidence rates and prevalence rising with every life year [1]. Beyond age, arterial hypertension, cardiomyopathies, obstructive sleep apnea, or valvular dysfunction confer increased risk [2,3].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
Conclusion: The relationship between snoring and obesity has not been well explored. This study among slum-dwelling Indian women found a significant relationship between snoring and obesity. Future research should explore the underlying mechanisms connecting snoring to BMI.
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
Genes, Vol. 11, Pages 461: An Integrative Phenotype–Genotype Approach Using Phenotypic Characteristics from the UAE National Diabetes Study Identifies HSD17B12 as a Candidate Gene for Obesity and Type 2 Diabetes Genes doi: 10.3390/genes11040461 Authors: Mahmood Y. Hachim Hayat Aljaibeji Rifat A. Hamoudi Ibrahim Y. Hachim Noha M. Elemam Abdul Khader Mohammed Albert Salehi Jalal Taneera Nabil Sulaiman The United Arab Emirates National Diabetes and Lifestyle Study (UAEDIAB) has identified obesity, hypertension, obstructive sleep apnea, and dyslipidemia as common phenotypic characteristics correlate...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
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