Enrollment and transition challenges in the International Maternal Pediatric and Adolescent AIDS Clinical Trials (IMPAACT) network's PROMISE trial for resource-limited regions.

CONCLUSIONS: Experiences from the PROMISE study illustrate the challenges of enrolling in longer term studies in the setting of rapidly evolving prevention and treatment standards priorities. The lessons learned will help the community, site investigators, and study coordinators in the design and implementation of future clinical trials. PMID: 32191142 [PubMed - as supplied by publisher]
Source: Clinical Trials - Category: Research Authors: Tags: Clin Trials Source Type: research

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Researchers using MRI to study blood flow through the placenta discovered a...Read more on AuntMinnie.comRelated Reading: Can ultrasound, 3D printing deepen maternal-fetal bonds? Third-trimester ultrasound finds undetected fetal abnormalities Gadolinium MRI scans most common early in pregnancy More pregnant women are undergoing imaging In utero MRI on par with ultrasound for fetal brain evaluation
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Conditions:   HIV/AIDS;   Pregnancy Related;   Congenital Disorders;   Newborn Morbidity Intervention:   Other: Pharmacovigilance surveillance program Sponsor:   Indiana University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The pressing need to expand the biomedical HIV prevention evidence base during pregnancy is now increasingly recognized. Women ’s views regarding participation in such trials and initiating PrEP while pregnant ...
Source: AIDS Research and Therapy - Category: Infectious Diseases Authors: Tags: Research Source Type: research
CONCLUSIONS: The majority of participants conveyed strong interest in participating in biomedical HIV prevention research during pregnancy, largely motivated by a desire to protect themselves and their offspring. Our results are consistent with other studies that found high acceptance of HIV prevention products during pregnancy, and support the current direction of HIV research policies and practices that are increasingly aimed at protecting the health of pregnant women and their offspring through responsible research, rather than defaulting to their exclusion. PMID: 32460804 [PubMed - in process]
Source: AIDS Research and Therapy - Category: Infectious Diseases Authors: Tags: AIDS Res Ther Source Type: research
This study aimed to determine the seroprevalence of anti-Toxoplasma gondii among pregnant women, HIV/AIDs and children in West Africa, Cameroon and Gabon. The epidemiology of the disease published between 1984 and 2019 using PubMed, Web of Science, Ovid MEDLINE, AJOL and Google Scholar databases were identified. Studies that met the inclusion criteria of Toxoplasma gondii infections under the preferred reporting items for systematic reviews and meta-analyses (PRISMA) checklist were analysed. A total of 58 eligible studies were selected for meta-analysis. These studies considered 18,674 hosts and an overall pooled seropreva...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
In conclusion, our findings show the importance of mNGS use to help characterize the outbreak more completely and in the management of the affected patients. PMID: 32422120 [PubMed - as supplied by publisher]
Source: Braz J Infect Dis - Category: Infectious Diseases Authors: Tags: Braz J Infect Dis Source Type: research
Survival and HIV-Free Survival Among Children Aged ≤3 Years - Eight Sub-Saharan African Countries, 2015-2017. MMWR Morb Mortal Wkly Rep. 2020 May 15;69(19):582-586 Authors: Jonnalagadda S, Yuengling K, Abrams E, Stupp P, Voetsch A, Patel M, Minisi Z, Eliya M, Hamunime N, Rwebembera A, Kirungi W, Mulenga L, Mushavi A, Ryan C, Ts'oeu M, Kim E, Dziuban EJ, Hageman K, Galbraith J, Mweebo K, Mwila A, Gonese E, Patel H, Modi S, Saito S Abstract Although mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) is preventable through antiretroviral treatment (ART) during pregnancy and post...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Providing antiretroviral treatment to women living with human immunodeficiency virus (HIV) infection before, during, and after pregnancy is critical for preventing mother-to-child transmission of HIV and improving child survival.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: HIV/AIDS MMWR Morbidity & Mortality Weekly Report Pregnancy Source Type: news
AbstractPoor HIV care retention impedes optimal treatment outcomes in persons living with HIV. Women trying to become pregnant may be motivated by periconception horizontal and vertical transmission concerns and thus more likely to attend HIV care visits than women not trying to conceive. We estimated the effect of fertility intentions on HIV care attendance over 12  months among non-pregnant, HIV-positive women aged 18–35 years who were on or initiating antiretroviral therapy in Johannesburg, South Africa. The percentage of women attending an HIV care visit decreased from 93.4% in the first quarter to 82.8...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
CONCLUSIONS: CHEU in rural Zimbabwe had total child development and vocabulary scores that were approximately 0.15 standard deviations lower than CHU at two years of age. More detailed and specific studies are now needed to unravel the reasons for developmental delay in CHEU and the likelihood that these delays persist in the longer term. PMID: 32386127 [PubMed - as supplied by publisher]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
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