Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo
An emerging problem in the treatment of breast cancer is the increasing incidence of metastases to the brain. Metastatic brain tumours are incurable and can cause epileptic seizures and cognitive impairment, s...
CONCLUSION: Structural prevention measures in addition to behavioral measures enable a reduction of the cancer risk caused by UV radiation. The aim must be to establish these measures nationwide for the entire population. PMID: 32494842 [PubMed - as supplied by publisher]
This study sought to determine the incidence rates of all gynecologic, including peritoneal, malignancies in the U.S. Active Duty population compared to the general US population as reported in the Surveillance, Epidemiology, and End Results Program database. MATERIALS AND METHODS: Gynecologic cancers diagnosed in U.S. Active Duty women aged 20-59 between 2004 and 2013 were retrospectively ascertained. Cancer cases were identified in both the Automated Central Tumor Registry and the Military Health System Data Repository. All cases in Automated Central Tumor Registry plus cases recorded in Military Health System Data R...
Publication date: Available online 5 June 2020Source: Gynecologic Oncology ReportsAuthor(s): Maryam Kasraeian, Kamran Hessami, Homeira Vafaei, Nasrin Asadi, Leila Foroughinia, Shohreh Roozmeh, Khadije Bazrfashan
Publication date: Available online 4 June 2020Source: Gynecologic Oncology ReportsAuthor(s): María Jesús Rubio, María José Lecumberri, Silvia Varela, Jesús Alarcón, María Eugenia Ortega, Lydia Gaba, Jaime Espinós, Julia Calzas, Pilar Barretina, Isabel Ruiz, Gloria Marquina, Ana Santaballa
CONCLUSIONS: Our data provide new insights into the biology driving metastasis in PTCs and highlight how lncRNAs cooperate with coding transcripts to sustain these processes. PMID: 32495722 [PubMed - as supplied by publisher]
Conclusion: Integrating preoperative nTMS motor mapping in treatment planning allowed us to reduce dose distributions to perilesional motor fibers while achieving salvage of motor function, lasting seizure freedom, and tumor control. These initial data along with our review of the available literature suggest that nTMS can be of significant assistance in brain radiosurgery. Prospective studies including larger number of patients are still warranted. PMID: 32257555 [PubMed - as supplied by publisher]
In conclusion, we suggested that valproate enhanced 3-BrPA-induced cell death. This might be attributable to the increase in cellular ATP consumption owing to valproate-induced MRP2 or BCRP expression.Graphical abstract
Authors: Abe K, Taira T Abstract The discovery that ultrasound waves could be focused inside the skull and heated to high temperatures at a focal point goes back to 1944. However, because the skull causes the ultrasound waves to attenuate and scatter, it was believed that application of this technology would be difficult, and that it would be impossible to use this approach in the surgical treatment of intracranial diseases. Eventually, magnetic resonance image guided focused ultrasound (MRgFUS) surgery began being used to treat uterine fibroids, breast cancer and bone metastasis and locally confined prostate cance...
Conclusion: 18F-FETrp tumoral uptake, biodistribution, and radiation dosimetry data provide strong preclinical evidence that this new radiotracer warrants further studies that may lead to a broadly applicable molecular imaging tool to examine abnormal tryptophan metabolism in human tumors.
CONCLUSIONS:[18F]FETrp tumoral uptake, biodistribution and radiation dosimetry data provide strong preclinical evidence that this new radiotracer is worth further studies that may lead to a new, broadly-applicable molecular imaging tool to study abnormal tryptophan metabolism in human tumors.