Autoimmunity in Acute Myocarditis: How Immunopathogenesis Steers New Directions for Diagnosis and Treatment
AbstractPurpose of ReviewOver the last decade, myocarditis has been increasingly recognized as common cause of sudden cardiac death in young adults and heart failure overall. The purpose of this review is to discuss hypothesis of development of non-infectious myocarditis, to provide a description of the immunopathogenesis and the most common mechanisms of autoimmunity in myocarditis, and to provide an update on therapeutic options.Recent FindingsA new entity of myocarditis is immune checkpoint inhibitor (ICI) induced myocarditis. ICIs are used in advanced cancer to “disinhibit” the immune system and make it more aggressive in fighting cancer. This novel drug class has doubled life expectancy in metastatic melanoma and significantly increased progression free survival in advanced non-small-cell lung cancer, but comes with a risk of autoimmune diseases such as myocarditis resulting from an overly aggressive immune system.SummaryMyocarditis is an inflammatory disease of the heart with major public health impact. Thorough understanding of its immunopathogenesis is crucial for accurate diagnosis and effective treatment.
Authors: Aparisi Á, Uribarri A Abstract Takotsubo syndrome is an acute cardiomyopathy that mimics acute coronary syndrome and is characterized by acute heart failure with reversible ventricular motion abnormalities, in the absence of justifying coronary artery disease. This document offers an exhaustive review of various proposed hypotheses that attempt to explain the pathophysiology of this disease and provides an updated review of the different classifications that have emerged in recent years. In addition, we describe the main clinical characteristics of these patients, the diagnostic tests that must be p...
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Publication date: Available online 20 June 2020Source: The Journal of Molecular DiagnosticsAuthor(s): Lynette M. Sholl, Diana Mandelker, Tracy Stockley
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Jie Zhang, Sujie Zhang, Xiaoyan Li, Fan Zhang, Lei Zhao
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Xianglin Yang, Xuelian Li, Xia Hao, Wen Tian, Baosen Zhou
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Yu-Peng Wu, Zhi-Bin Ke, Fei Lin, Yao-An Wen, Sheng Chen, Xiao-Dong Li, Shao-Hao Chen, Xiong-Lin Sun, Jin-Bei Huang, Qing-Shui Zheng, Xue-Yi Xue, Yong Wei, Ning Xu
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Leonardo Franz, Lara Alessandrini, Giancarlo Ottaviano, Roberto di Carlo, Elena Fasanaro, Giulia Ramacciotti, Giacomo Contro, Gino Marioni
Probiotics are living microorganisms, which when taken in adequate amount, provide various health benefits by maintaining the balance of bacteria in the intestine. Probiotics are purported to have countless health benefits, some of which include improved digestion, enhanced immunity, prevention of cancer and diabetes. The most common group of probiotics include species of Lactobacillus, Bifidobacterium and Enterococcus. In order to work as an effective probiotic, the microbial strain is expected to exhibit certain desirable characteristics like acid and bile tolerance, antimicrobial activity, adhesion to intestinal epithel...
Conclusion: The detailed research on the patent information presented herein focused on the activity of the compositions containing jackfruit extract and isolated phytochemicals would assist researchers to understand the mechanisms by which the bio-chemicals exert their effect and the overall nutritional benefits. An increase in the number of publications and patents in recent years related to the use of jackfruit for different health conditions clearly emphasizes its therapeutic potential and importance as medicinal food products and cosmetics.
The objective of this study was to develop functional dark chocolate with improved organoleptic, textural and functional attributes by optimizing the ingredients levels such as flaxseed oil and honey and its further validation for quality improvement. Methods: The chocolate composition was optimized by selecting two variables including flaxseed oil (1-2.5g) and honey (10-15g) at 3 levels in central composite rotatable design (CCRD) by using Design- Expert version 11 software tool. Results: After optimization, the best-predicted formulation comprising flaxseed oil 2.37% (w/w) and honey 15% (w/w) showed best sensorial score (p