Predicting toxicity for Head and Neck cancer patients undergoing radiation therapy: an independent and external validation of MDASI-HN based nomogram

Publication date: Available online 19 March 2020Source: Reports of Practical Oncology &RadiotherapyAuthor(s): Nishant Vidyasagar, Janaki Manur Gururajachar
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research

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Conclusions: Hypothyroidism and difficult airways are a common sequel of RT. Selected cancer patients with subclinical hypothyroidism had a smooth perioperative course.
Source: Indian Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
Condition:   Head and Neck Squamous Cell Carcinoma Intervention:   Radiation: Intensity-modulated Radiation Therapy (IMRT) Sponsor:   University of Texas Southwestern Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
To review a single institutional experience of the Radiation Therapy Oncology Group (RTOG) 8502 “QUAD shot” regimen using volumetric modulated arc radiotherapy (VMAT) for incurable head and neck cancer (HNC).
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Periodontal disease (PD) is a common oral complication in patients with head and neck cancer (HNC) undergoing radiation therapy (RT). Our objective was to identify candidate single nucleotide polymorphisms (SNPs) associated with PD in radiation-treated patients with HNC.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Collectively, the studies presented herein suggest that tyrosine 821 of AXL mediates resistance to cetuximab by activation of c-ABL kinase in HNSCC and that targeting of both EGFR and c-ABL leads to a robust anti-tumor response. PMID: 32439698 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
This study extends the findings from a recent systematic review by the current authors which concentrated on tumour outcomes for PT, to now examine toxicity as a separate focus. Together, these reviews provide a comprehensive collation of the evidence relating to PT outcomes in clinical practice. Three major databases were searched by two independent researchers, and evidence quality was classified according to the National Health and Medical Research Council evidence hierarchy. One hundred and seventy ‐nine studies were included. Most demonstrated acceptable and favourable toxicity results. Comparative evidence reported...
Source: Journal of Medical Imaging and Radiation Oncology - Category: Radiology Authors: Tags: Radiation Oncology —Review Article Source Type: research
Abstract Head and neck cancer (HNC), which includes epithelial malignancies of the upper aerodigestive tract (oral cavity, oropharynx, pharynx, hypopharynx, larynx, and thyroid), are slowly but consistently increasing, while the overall survival rate remains unsatisfactory. Because of the multifunctional anatomical intricacies of the head and neck, disease progression and therapy-related side effects often severely affect the patient's appearance and self-image, as well as their ability to breathe, speak, and swallow. Patients with HNC require a multidisciplinary approach involving surgery, radiation therapy, and ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Radiation-associated dysphagia (RAD) is one of the severe sequelae of treatment in head and neck (HNC) cancer patients undergoing radiation therapy (RT), with chronic toxicity arising even after acute symptoms have ceased [1]. Chronic RAD is even more relevant in the era of Human Papillomavirus associated (HPV) HNC, where the majority of patients have curable disease with prolonged survival, and thereby endure later toxicities which are otherwise not encountered in patients with aggressive HPV negative disease and relatively shorter survival duration.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Facial Plast Surg 2020; 36: 141-147 DOI: 10.1055/s-0040-1709132High-risk nonmelanoma skin cancers of the head and neck may be identified through a variety of tumor risk factors, including location on the lips or ears, size > 2 cm, recurrence, patient immunocompromised status, poor tumor differentiation, > 6 mm thickness, Clark level V depth of invasion, and presence of perineural spread. Surgical excision is the mainstay of treatment, with Mohs' micrographic surgery typically preferred to standard surgical excision. When reconstructing these defects, ensuring negative margins...
Source: Facial Plastic Surgery - Category: Cosmetic Surgery Authors: Tags: Original Article Source Type: research
Abstract PURPOSE: Using a 200 Head and Neck cancer (HNC) patient cohort, we employ patient similarity based on tumor location, volume, and proximity to organs at risk to predict radiation-associated dysphagia (RAD) in a new patient receiving intensity modulated radiation therapy (IMRT). MATERIAL AND METHODS: All patients were treated using curative-intent IMRT. Anatomical features were extracted from contrast-enhanced tomography scans acquired pre-treatment. Patient similarity was computed using a topological similarity measure, which allowed for the prediction of normal tissues' mean doses. We performed feat...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
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