Revealing Developmental Regionalization of Infant Cerebral Cortex Based on Multiple Cortical Properties.

Revealing Developmental Regionalization of Infant Cerebral Cortex Based on Multiple Cortical Properties. Med Image Comput Comput Assist Interv. 2019 Oct;11765:841-849 Authors: Wang F, Lian C, Wu Z, Wang L, Lin W, Gilmore JH, Shen D, Li G Abstract The human brain develops dynamically and regionally heterogeneously during the first two postnatal years. Cortical developmental regionalization, i.e., the landscape of cortical heterogeneity in development, reflects the organization of underlying microstructures, which are closely related to the functional principles of the cortex. Therefore, prospecting early cortical developmental regionalization can provide neurobiologically meaningful units for precise region localization, which will advance our understanding on brain development in this critical period. However, due to the absence of dedicated computational tools and large-scale datasets, our knowledge on early cortical developmental regionalization still remains intact. To fill both the methodological and knowledge gaps, we propose to explore the cortical developmental regionalization using a novel method based on nonnegative matrix factorization (NMF), due to its ability in analyzing complex high-dimensional data by representing data using several bases in a data-driven way. Specifically, a novel multi-view NMF (MV-NMF) method is proposed, in which multiple distinct and complementary cortical properties (i.e., multiple views) are joi...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research