Radiotherapy planning and Molecular Imaging in Lung Cancer.
Radiotherapy planning and Molecular Imaging in Lung Cancer. Curr Radiopharm. 2020 Mar 18;: Authors: Filice A, Casali M, Ciammella P, Galaverni M, Fioroni F, Lotti C, Versari A Abstract The goal of the radiotherapy (RT) planning process is to select and delineate target volumes with the best accuracy on the basis of all the available diagnostic information and the knowledge of the physiology of the disease. The recommendation of the International Atomic Energy Agency (IAEA) expert panel, is that an appropriately timed and technically adequate 2-[18F]fluoro-2-deoxy-d-glucose/Positron Emission Tomography-Computer Tomography (18F-FDG-PET/CT) imaging is an essential component in the radiotherapy treatment planning (RTP) process for lung cancer . Each patient considered for radical radiotherapy should have had a staging 18F-FDG-PET/CT for RTP, acquired in treatment position and co-registered with the planning CT . When used without specific adaptations for RTP, 18F-FDG-PET/CT scan can be visually correlated with the RTP CT to identify areas of disease to be included in the treatment volume. Technically the best available option is to acquire an 18F-FDG-PET/CT scan exclusively for the purpose of RTP. This scan may be performed when a staging PET has already been acquired and the patient is deemed suitable for radical radiotherapy. This approach requires two separate PET scans, which has an advantage that it removes any staging or patient selection issues b...
Nature Reviews Clinical Oncology, Published online: 26 May 2020; doi:10.1038/s41571-020-0393-zLung cancer screening is currently based only on low-dose CT scans; however, novel, more accessible methods that might improve uptake and adherence are eagerly awaited. New liquid biopsy approaches promise to revolutionize cancer screening. Herein, we discuss the opportunities and challenges associated with two such novel assays.
This study explored patient experience of MR treatment planning scans in addition to a CT scan.
ConclusionsTreatment of patients with relapsed solid tumors with 7.5 mg/d E and 800 mg/d S is safe and feasible. Early metabolic response in FDG‐PET was not confirmed in CT scan several weeks later. The combination of S and E is obviously not sufficient to induce durable responses in patients with KRAS‐mutant solid tumors.
Conclusion: Anti-GABA-B receptor encephalitis mainly occurred in middle-aged and elderly men, and the disease onset was relatively sudden. Before disease onset, some patients experienced fever and non-specific respiratory symptoms, which mainly manifested as frequent epileptic seizures, cognitive dysfunction, and abnormal mental behavior. MRI and PET-CT revealed abnormal signals and local metabolism, respectively, in the temporal lobe. Moreover, the disease has a close relationship with lung cancer, which requires long-term follow-up observation.
Condition: Lung Cancer Intervention: Device: PET/CT Sponsor: Assiut University Not yet recruiting
CONCLUSIONS: Weekly docetaxel and platinum-based drug doublet combined with TR yielded promising results in stage III NSCLC, with high survival rates. The toxicity of this association is acceptable, with mainly manageable esophagitis. These findings warrant validation in a prospective study before considering this association for standard of care. PMID: 32439358 [PubMed - as supplied by publisher]
Abstract BACKGROUND: Adherence to annual low-dose computed tomography was 95% in the National Lung Screening Trial and must be replicated in order to achieve mortality benefit from screening. RESEARCH QUESTION: Determine adherence rates within the Veterans Affairs Lung Cancer Screening Demonstration Project (LCSDP) and identify factors predictive of adherence. STUDY DESIGN: and Methods: A secondary data analysis of the LCSDP conducted at 8 VA medical centers was performed to determine adherence to follow-up imaging and determine factors predictive of adherence. RESULTS: A total of 2103 patients were...
The objective of this study was to develop a clinical model for predicting small thymomas (
In this study, 226 patients with resected lung cancers were enrolled. DWI was performed on each patient before surgery. There were 167 patients with adenocarcinoma, 44 patients with squamous cell carcinoma, and 15 patients with other cell types. Relationships between the apparent diffusion coefficient (ADC) of DWI and the pathology were analyzed. When the optimal cutoff value (OCV) of ADC for diagnosing malignancy was 1.70 × 10−3 mm2/s, the sensitivity of DWI was 92.0% (208/226). The sensitivity was 33.3% (3/9) in mucinous adenocarcinoma. The ADC value (1.31 ± 0.32 × 10−3 mm2/s) of adenocarci...
We report a mean 3D Dice score of 88.6% on an NHL hold-out set of 1124 scans and a 93% sensitivity on 274 NSCLC hold-out scans. The method is a potential tool for radiologists to rapidly assess eyes to thighs FDG-avid tumor burden.