Pediatric glomerular hematuria: a clinicopathological study
AbstractBackgroundHematuria is a common problem in pediatric practice and necessitates exhausting studies to detect etiology and establish proper management and counselling.Subjects and methodsWe reviewed the clinical and pathological findings in 95 children presented between 2013 and 2019 with gross or microscopic hematuria with or without proteinuria in whom non-glomerular causes were excluded. In addition, a reference range for normal glomerular basement membrane thickness (GBMT) is introduced based on the assessment of biopsies of 20 steroid-resistant nephrotic syndrome cases aged 3 –15 years, and with minimal change pathology.ResultsFifty-seven males and 38 females with a mean age of 7.72 ± 3.27 years were included. Recurrent gross hematuria was the most frequent presentation (42%) while accidentally discovered hematuria was reported in 34.7% of patients. Alport syndrome (AS) was the most frequent diagnosis (66.3%) followed by thin basement membrane disease (TBMD) (29.5%) an d Immunoglobulin A nephropathy (IgAN) (4%). A reference for normal GBMT was 360.3 ± 87.5 nm which is comparable to published references. Males with AS had a higher incidence of progression to renal failure and requirement for dialysis (p = 0.006 and 0.03, respectively) compared to females. Persistent proteinuria and lower glomerular filtration rate at diagnosis were associated with poor outcomes (p
Egypt confirmed 1,399 new cases of the novel coronavirus on Monday, the health ministry said, its first decline for a week.
Publication date: Available online 31 May 2020Source: Journal of Food Composition and AnalysisAuthor(s): Ahmed Salem Sebaei, Hoda M. Refai, Hannah Tarek Elbadry, Sandra Mounir Armeya
ABSTRACT The indication for simultaneous bilateral native nephrectomy and the choice of surgical technique is of key importance, as these patients are burdened with a large comorbidity. The paper reports our experience of seven successful and completed simultaneous bilateral native nephrectomy procedures with retroperitoneal approach in the patient ’ s flank position. Seven patients (mean age 34), were indicated for the removal of both kidneys before the planned transplant. Six patients underwent haemodialysis from 48 to 84 months, and one underwent peritoneal dialysis for 60 months. Two patients had undergone grafte...
Conditions: End Stage Renal Failure on Dialysis; Arteriovenous Graft Occlusion Interventions: Device: Sirolimus coated balloon; Device: Plain balloon Sponsors: Singapore General Hospital; National University Hospital, Singapore; Sengkang General Hospital Not yet recruiting
Condition: Cost Effectiveness Intervention: Other: Education and counseling Sponsor: Ain Shams University Recruiting
Condition: Anemia Associated With End Stage Renal Disease (ESRD) Intervention: Drug: Roxadustat Sponsors: FibroGen; AstraZeneca Not yet recruiting
Condition: Molar Incisor Hypomineralization Intervention: Diagnostic Test: Mirror and prope Sponsor: Eman Zakaria Ali Hashem Not yet recruiting
Conclusions: These findings question the usefulness of (TIMP-1) × (IGFBP-7) for the prediction of cardiac surgery-related acute kidney injury in neonates and infants when measured within 3 hours of cardiopulmonary bypass.
There are more than 660,000 Americans with kidney failure and nearly 470,000 on dialysis.1 Of these, estimates of nonvalvular atrial fibrillation (NVAF) approach 20%.2 Atrial fibrillation nearly doubles the anticipated mortality and increases the stroke risk by approximately six-fold in these patients. The intersection between end-stage renal disease (ESRD) and NVAF is complicated and not easily parsed. Atrial fibrillation likely increases the rate of progression to ESRD in patients with underlying chronic kidney disease (CKD).
Gestational hypertension (GH) is defined as an increase of blood pressure (BP ≥ 140/90 mm Hg) arising after 20 weeks of gestation in the absence of significant proteinuria, biochemical or haematological abnormalities and new signs of end-organ dysfunction and is usually not accompanied by fetal growth restriction. Its incidence is worldwide estimated as 4-17% in null iparous women and 2-4% in multiparous women, but it is even higher in women with previous preeclampsia (PE) . One in 50 hypertensive women in their pregnancy develop essential hypertension by the time of their next pregnancy .