Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives.

CONCLUSION: The 3-(acridin-9-ylmethyl)-5-((10-chloroanthracen-9-yl)methylene)thiazolidine-2,4-dione (LPSF/AA-62) presented the most promising results, showing anti-tumor activity in 5 of the 6 cell types tested, especially inhibiting the formation of colonies of prostate tumor cells (DU-145). PMID: 32189590 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32189590?dopt=Abstract

Source: Combinatorial Chemistry and High Throughput Screening - March 17, 2020 Category: Chemistry Authors: de Almeida ML, Viana D, Costa V, Santos F, Pereira M, Pitta M, Rêgo M, Pitta I, Galdino-Pitta M Tags: Comb Chem High Throughput Screen Source Type: research