Frequency, Risk Factors, and Outcome of Active Tuberculosis following Allogeneic Hematopoietic Stem Cell Transplantation

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment for hematologic malignancies and nonmalignant diseases. Furthermore, haploidentical stem cell transplantation has been developed in the past 2 decades as another potential strategy for patients with no HLA-matched donor.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research

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Latent tuberculosis infection (LTBI) is a global health problem estimated to affect at least one out of every four people in the world [1]. Recent changes in sociodemographic paradigms during the latter part of the 20th century, have made of LTBI an important clinical and socioeconomic challenge, particularly in developing countries [2,3]. Incidence of LTBI varies widely between geographical regions, ranging from 3.3 and 11.9 cases per 100,000 individuals in the United States and the European Union, respectively, to 100 cases per 100,000 individuals in Africa [4,5,6].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: Original Article Source Type: research
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment for hematological malignancies and nonmalignant diseases. Furthermore, haploidentical stem cell transplantation has been developed in the past two decades as another potential strategy for patients with no HLA-matched donor.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
BCG vaccination is an important global health measure in countries with endemic tuberculosis but poses significant risks when administered to patients with Severe Combined Immune Deficiency (SCID) or genetic defects associated with Mendelian Susceptibility to Mycobacterial Diseases (MSMD). A study by Marciano et al. reported that BCG-osis occurred in over 50% of BCG-vaccinated patients with SCID. The impact of this infection on allogeneic hematopoietic stem cell transplant (HSCT) outcomes is unclear.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 529 Source Type: research
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsWe found that MSCs combined with hydroxyapatite represents a potential therapy for bone regeneration in VBD. Further clinical studies are required to investigate the safety and efficacy of this combination of therapy in VBDs.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionA high suspicion level for TB, the early diagnosis and the prompt initiation of therapy could increase the survival rates among SOT patients. Overall, renal and lung TRs appear to have a higher predisposition for acquiring TB than other type of recipients. Monitoring of the high-risk recipients, prompt diagnosis, and appropriate treatment are required to manage TB infection among TRs especially in endemic areas.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice. Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: Allogeneic HSCT is an effective therapy for high-risk hematological malignancies in patients with HIV infection, and long-term HIV suppression with combination antiretroviral therapy is feasible. However, drug interactions with antiretroviral agents, occurrence of GVHD, and frequent infectious complications account for a complex procedure in this population. Selected HIV-infected patients with hematologic malignancies should be considered for allo-HSCT when indicated, in experienced centers.
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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