What Works Best to Ease the Pain of Sciatica?
Title: What Works Best to Ease the Pain of Sciatica?Category: Health NewsCreated: 3/18/2020 12:00:00 AMLast Editorial Review: 3/19/2020 12:00:00 AM
Title: Got Sciatica? Stay Active and Start Early on Physical TherapyCategory: Health NewsCreated: 10/5/2020 12:00:00 AMLast Editorial Review: 10/6/2020 12:00:00 AM
Conclusions: A current smoking status and higher nicotine dependence increase the odds for chronic LBP, sciatica and radicular neuropathic pain. PMID: 32989201 [PubMed]
Conditions: Chronic Low Back Pain; Chronic Sciatica; Lumbar Spinal Stenosis; Lumbar Disc Herniation; Lumbar Spondylolisthesis; Lumbago; Lumbar Disc Degeneration; Persistent Postoperative Pain Intervention: Other: Zhineng Qigong intervention Sponsors: Lund University; The Swedish Institute for Health Sciences; Ekhaga foundation; Greta and Johan Kock Foundation Completed
Title: Degenerative Disc Disease and SciaticaCategory: Diseases and ConditionsCreated: 12/4/1998 12:00:00 AMLast Editorial Review: 7/14/2020 12:00:00 AM
Conclusion: Tetrapanax papyriferus and hederagenin relieved sciatica by reducing inflammation levels, inhibiting p38 MAPK phosphorylation, and decreasing the levels of dorsal root ganglion proteins. PMID: 32617100 [PubMed]
Abstract INTRODUCTION: The treatment of chronic low back pain (cLBP) often involves multimodal pharmacologic and non-pharmacologic strategies. There remain shortcomings with these tools with regards to both effect size and side effects. AREAS COVERED: In an effort to better address cLBP, anti-nerve growth factor (NGF) monoclonal antibodies (mAbs) are nearing marketing approval. This class of medications has been primarily evaluated for osteoarthritis, but are being examined at higher doses for use in cLBP. We review the efficacy of this class in treating LBP as well as their potential side effects based on ni...
In conclusion, this study is the first to report genetic overlap between regulatory processes implicated in CPSP and chronic peripheral pain syndromes. Interaction between neurological signalling and inflammatory res ponse may explain the genetic overlap between CPSP, CWP and RA. Enhanced understanding of mechanisms underlying chronification of pain will aid the development of new therapeutic strategies for CPSP with sodium channel biochemistry as a potential candidate.
CONCLUSIONS: This updated Cochrane Review included 32 trials to evaluate the efficacy of NSAIDs in people with acute LBP. The quality of the evidence ranged from high to very low, thus further research is (very) likely to have an important impact on our confidence in the estimates of effect, and may change the estimates. NSAIDs seemed slightly more effective than placebo for short-term pain reduction (moderate certainty), disability (high certainty), and global improvement (low certainty), but the magnitude of the effects is small and probably not clinically relevant. There was no clear difference in short-term pain reduct...