Intact B-Cell Signaling and Function With Host B-Cells 47 Years After Transplantation for X-SCID

Conclusions: Even with host B cells, reconstitution with donor T cells can be sufficient to allow over four decades of survival when B-cell function is intact. Our case demonstrates that satisfactory B-cell function can arise as a consequence of both intact IL-21 signaling due to a hypomorphic γc variant, and close HLA matching with the donor to allow for effective T-cell help.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research