IL-18/IL-18R1 promotes circulating fibrocyte differentiation in the aging population

ConclusionCirculating fibrocytes from elders had an enhanced capacity to differentiate into myofibroblasts, and might contribute to age-dependent fibrosis. Age-dependent increment of differentiation at least in part arose from their enhanced expression of IL-18R1. Inhibiting fibrocyte differentiation might be useful as an adjuvant treatment to delay the fibrosis process in aging population.
Source: Inflammation Research - Category: Research Source Type: research