Mitochondrial Complex I Inhibition by Metformin: Drug-Exercise Interactions.

Mitochondrial Complex I Inhibition by Metformin: Drug-Exercise Interactions. Trends Endocrinol Metab. 2020 Apr;31(4):269-271 Authors: Martín-Rodríguez S, de Pablos-Velasco P, Calbet JAL Abstract Metformin has antidiabetic, anticancer, and prolongevity effects, but seems to interfere with aerobic training mitochondrial adaptations. The primary mechanism of action has been suggested to be the inhibition of mitochondrial complex I. Recent papers (Wang et al. and Cameron et al.), however, provide evidence to deny the hypothesis of a direct action of metformin on complex I. PMID: 32187522 [PubMed - as supplied by publisher]
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Tags: Trends Endocrinol Metab Source Type: research