Proton Therapy Reduces Patient Side Effects, Possible ‘Game Changer’

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Source: Oncology Times - Category: Cancer & Oncology Tags: News Source Type: research

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The targeting accuracy of proton therapy (PT) for moving soft-tissue tumours is expected to greatly improve by real-time magnetic resonance imaging (MRI) guidance. The integration of MRI and PT at the treatmen...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Discussion: Incorporation of PBT into our existing cancer center allowed for multidisciplinary oncologic treatment of a diverse population of patients. Insurance coverage for PBT presents as a significant hurdle and improvements are needed to provide more timely access to necessary oncologic care.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Whole-pelvis pencil beam scanning (PBS) proton therapy is utilized in both the intact and post-operative settings in patients with prostate cancer. As whole pelvis prostate radiotherapy has traditionally been delivered with standard photon beams, limited evidence and technical descriptions have been reported regarding the use of proton therapy. Here we present two robust three-field treatment planning approaches utilized to maximize target coverage in the presence of anatomic and delivery uncertainties.
Source: Medical Dosimetry - Category: Radiology Authors: Source Type: research
CONCLUSION: An automated framework for running MC calculations was developed which enables the calculation of dose and linear energy transfer within a clinically relevant workflow and timeline. The models and framework were validated against patient specific QA measurements and exhibited excellent agreement. Before this implementation, execution was prohibitively complex for an untrained individual and its use restricted to a research environment. PMID: 32452657 [PubMed - as supplied by publisher]
Source: Journal of Applied Clinical Medical Physics - Category: Physics Authors: Tags: J Appl Clin Med Phys Source Type: research
Publication date: Available online 24 May 2020Source: Practical Radiation OncologyAuthor(s): Jing Zeng, Shahed N. Badiyan, Yolanda I. Garces, Tony Wong, Xiaodong Zhang, Charles B. Simone, Joe Y. Chang, Antje C. Knopf, Shinichiro Mori, Hiromitsu Iwata, Arturs Meijers, Heng Li, Martin Bues, Wei Liu, Steven E. Schild, Ramesh Rengan, International Particle Therapy Co-operative Group (PTCOG) Thoracic Subcommittee
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
ute;n Miguel Ardid A full chain simulation of the acoustic hadrontherapy monitoring for brain tumours is presented in this work. For the study, a proton beam of 100 MeV is considered. In the first stage, Geant4 is used to simulate the energy deposition and to study the behaviour of the Bragg peak. The energy deposition in the medium produces local heating that can be considered instantaneous with respect to the hydrodynamic time scale producing a sound pressure wave. The resulting thermoacoustic signal has been subsequently obtained by solving the thermoacoustic equation. The acoustic propagation has been simulated b...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
To investigate the role of intensity-modulated proton therapy (IMPT) compared to volumetric modulated arc therapy (VMAT), realised with RapidArc and RapidPlan methods (RA_RP) for neoadjuvant radiotherapy in lo...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
The use of a specific treatment technique in radiation therapy is mainly motivated by the achievable dose conformity to the target and the overall integral dose. Proton therapy offers a highly conformal and comprehensive treatment option with a lower integral dose (reduced low-dose bath) to organs at risk (OARs). Consequently, given the proximity of cardiopulmonary structures, proton therapy has been discussed as a treatment alternative for breast cancer patients [1 –3]. Treatment planning studies, comparing 3DCRT, IMRT, and proton therapy when irradiating the breast and regional nodes showed advantages of using prot...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Publication date: Available online 22 May 2020Source: Life Sciences in Space ResearchAuthor(s): Livio Narici, Elena Titova, André Obenaus, Andrew Wroe, Lilia Loredo, Reinhard Schulte, Jerry D. Slater, Gregory A. Nelson
Source: Life Sciences in Space Research - Category: Biology Source Type: research
Abstract Purpose: To study the potential consequences of differences in the evaluation of variable versus uniform relative biological effectiveness calculations in proton radiotherapy for prostate cancer.Methods and material: Experimental data with proton beams suggest that relative biological effectiveness increases with linear energy transfer. This relation also depends on the [Formula: see text] ratio, characteristic of a tissue and a considered endpoint. Three phenomenological models (Carabe et al., Wedenberg et al. and McNamara et al.) are compared to a mechanistic model based on microdosimetry...
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
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