Letter to the editor concerning the article ‘Association between rotavirus vaccination and risk of intussusception among neonates and infants: a systematic review and meta-analysis’ (JAMA Netw Open. 2019;2(10):e1912458)

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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research

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The objectives were to evaluate vaccine efficacy (VE) against RVGE of any-severity, severe RVGE (sRVGE) and inpatient caused by rotavirus serotypes contained in the vaccine and not contained in the vaccine after the third dose. Immunogenicity was also assayed in a subgroup. All adverse events (AEs) were collected from 30 min after each dose for immediate reaction, even to the entire study period, including the serious AEs (SAEs) and intussusception. RESULTS: VE against RVGE of any-severity, sRVGE and inpatient caused by any serotype was 56.6% (95% CI: 50.7, 61.8), 70.3% (95% CI: 60.6, 77.6) and 74.0% (95% CI: 57....
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Corrigendum to "Epidemiology study of pediatric primary intussusception aged ≤24 months in pre-rotavirus vaccine era of Jinan, China" [Vaccine 37(11) (2019) 1436-1442]. Vaccine. 2020 Feb 11;: Authors: Yu X, Zhang T, Cui L, Geng X, Zhang J PMID: 32057579 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
We examined the effect of RotaTeq® vaccination on rotavirus and all-cause gastroenteritis hospitalisation rates using Poisson regression. Adjusted incidence rate ratios controlled for sex, year of birth, ethnicity, socioeconomic deprivation, and district health board area. RESULTS: Significant reductions in the incidence of rotavirus hospitalisation were seen in all age groups, ethnicities, and deprivation following the introduction of RotaTeq®. There was a 92.6% reduction in hospitalisation incidence in the vaccinated cohort (p 
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
This Viewpoint uses experience with rotavirus vaccine –induced intussusception and dengue virus vaccine–induced shock syndrome to discuss issues of disease prevalence and severity underlying recommendations the vaccines be used widely, and it reviews the systems in place to monitor vaccine safety that broadly favor vaccine benefits over risks to in dividuals and society.
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
Publication date: November 2019Source: The Lancet Global Health, Volume 7, Issue 11Author(s): Andrew Clark, Jacqueline Tate, Umesh Parashar, Mark Jit, Mateusz Hasso-Agopsowicz, Nicholas Henschke, Benjamin Lopman, Kevin Van Zandvoort, Clint Pecenka, Paul Fine, Colin SandersonSummaryBackgroundInfant rotavirus vaccines have led to substantial reductions in hospital admissions and deaths due to gastroenteritis, but some studies have reported an elevated risk of intussusception, a rare bowel disorder. This analysis aimed to provide evidence on the potential mortality reduction benefits and intussusception risks of current rotav...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Bhaskar Raju, Raunak P Parikh, Volker V Vetter, Shafi KolhapureIndian Journal of Public Health 2019 63(3):243-250 Rotavirus is a leading cause of severe pediatric diarrhea worldwide, with about 199,000 childhood deaths in 2015, of which 90% in low-income countries. India alone accounts for 22% of the global rotavirus gastroenteritis (RVGE)-related deaths among children below 5 years of age. The World Health Organization recommends introducing rotavirus vaccines (RVVs) as a priority in developing countries where high rates of RVGE are observed. To have the desired impact, RVV should be administered the earliest pos...
Source: Indian Journal of Public Health - Category: International Medicine & Public Health Authors: Source Type: research
Corrigendum to "Epidemiology study of pediatric primary intussusception aged ≤24 months in pre-rotavirus vaccine era of Jinan, China" [Vaccine (37) 1436-1442]. Vaccine. 2019 Sep 10;: Authors: Yu X, Zhang T, Cui L, Geng X, Zhang J PMID: 31519447 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Purpose of review As of 2019, four rotavirus vaccines have been prequalified by the WHO for use worldwide. This review highlights current knowledge regarding rotavirus vaccines available, and provides a brief summary of the rotavirus vaccine pipeline. Recent findings Data generated from use of currently available products supports their effectiveness and impact in diverse settings. Rotavirus vaccines have a favorable risk–benefit profile, but previous associations of rotavirus vaccination with intussusception necessitate continued monitoring for this rare but serious adverse event. Implementation of rotavirus va...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: GASTROINTESTINAL INFECTIONS: Edited by Gagandeep Kang and Eric R. Houpt Source Type: research
AbstractBackgroundIn some countries that have introduced oral rotavirus vaccines, a small but elevated risk of intussusception —a rare bowel disorder—has been reported. Updated estimates on the global epidemiology of intussusception are needed to help predict the potential number of intussusception cases that could be caused by the vaccine in different settings.MethodsWe estimated incidence rates, age distributions and case-fatality ratios (CFRs) for intussusception hospital admissions among children aged
Source: International Journal of Epidemiology - Category: Epidemiology Source Type: research
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