Ageing dangerously; homing of senescent CD8 T cells in cutaneous Leishmaniasis.
Ageing dangerously; homing of senescent CD8 T cells in cutaneous Leishmaniasis.
Immunology. 2020 Apr;159(4):355-356
Authors: Milling S
Abstract
Both CD8+ T cells and NK cells contribute to the immune response against the protozoan Leishmania parasite. Both are able to generate IFN-γ and both display cytotoxic features. These features may enable them to not only contribute to parasite clearance but also to cause immune-mediated pathology. This pathology is evident, for example, in the Leismania-induced skin lesions found in patients with cutaneous leismaniasis (CL). Here we highlight new data demonstrating that CD8+ T cells and NK cells in CL display a highly cytotoxic senescent phenotype, and that the senescent T cells play a major role in mediating skin pathology. This is the first demonstration that senescent CD8 T cells contribute to immunopathology in vivo.
PMID: 32182636 [PubMed - in process]
Source: Immunology - Category: Allergy & Immunology Authors: Milling S Tags: Immunology Source Type: research
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