Intermittent CPAP limits hyperoxia induced lung damage in a rabbit model of bronchopulmonary dysplasia.

Intermittent CPAP limits hyperoxia induced lung damage in a rabbit model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2020 Mar 18;: Authors: Gie AG, Salaets T, Vignero J, Regin Y, Vanoirbeek JA, Deprest J, Toelen J Abstract A significant proportion of preterm infants develop bronchopulmonary dysplasia (BPD) leading to poor lifelong respiratory health. Limited treatment options exist with continuous positive airway pressure ventilation (CPAP) being one of the few associated with diminished BPD. However, little is known on the effect of the distending pressure of CPAP on the developing lung exposed to hyperoxia. We aimed to identify the functional and structural effects of CPAP in the preterm hyperoxia rabbit model of BPD. Premature rabbit pups were randomized to normoxia, hyperoxia (≥95% O2) or hyperoxia plus 4 hours daily CPAP (FiO2 0.95, 5cm H2O). On day 7 post-delivery we performed invasive pressure-volume and forced oscillation based pulmonary function tests, prior to lung harvest for histological evaluation. Alveolar and vascular morphology, airway smooth muscle, respiratory epithelium height, extracellular matrix components and inflammatory cytokine expression were quantified. Hyperoxia-reared pups had restrictive lungs: alveolar walls were thickened, with the lung parenchymal tissue, collagen content and airway smooth muscle content increased. In addition, peripheral pulmonary artery wall thickness was increased. CPAP incre...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

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Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
Authors: PMID: 32454498 [PubMed - as supplied by publisher]
Source: Neonatology - Category: Perinatology & Neonatology Tags: Neonatology Source Type: research
CONCLUSION: Up to 49% of NICUs had low PNC use and low BPD rates, without a difference in mortality. Infants hospitalized in NICUs with a stated policy of low PNC use did not have an increased risk of BPD. PMID: 32454484 [PubMed - as supplied by publisher]
Source: Neonatology - Category: Perinatology & Neonatology Authors: Tags: Neonatology Source Type: research
An amendment to this paper has been published and can be accessed via the original article.
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Correction Source Type: research
Conclusion Infants with BPD are prone to develop gut dysbiosis in early life. A higher severity of illness and treatment intensity may indicate a higher risk of disrupting an anaerobic environment in the gut during the first month of life. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
This study aimed to review early bCPAP pressures and bCPAP failure with the RAM cannula interface over a 6-year period. Study Design Retrospective, single-center study of infants delivered
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
Am J Perinatol DOI: 10.1055/s-0040-1710353 Objective We aimed to determine the independent effect of maternal antepartum hemorrhage (APH) on mortality and major neonatal morbidities among very low birth weight (VLBW), very preterm infants. Study design A population-based cohort study of VLBW singleton infants born at 24 to 31 weeks of gestation between 1995 and 2016 was performed. Infants born with the following pregnancy associated complications were excluded: maternal hypertensive disorders, prolonged rupture of membranes, amnionitis, maternal diabetes, and small for gestational age. APH included hemorrha...
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
Abstract BACKGROUND: Bronchopulmonary dysplasia (BPD) is the most common respiratory disorder in extremely low birth weight infants. Although most BPD symptoms improve, some late complications exist, even with regular treatment. Gastroesophageal reflux (GER), also common in extremely premature infants, may be related to many cardiorespiratory symptoms. However, the potential of GER as a risk factor for late complications associated with BPD is still unclear. RESEARCH QUESTION: Does GER increase the risk of late complications of BPD in infants? STUDY DESIGN: and Methods: A multi-center prospective cohort ...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Abstract Within the human lung, mast cells typically reside adjacent to the conducting airway, and assume a "mucosal" phenotype (MCT). In rare pathological conditions, "connective tissue" phenotype mast cells (MCTC) can be found in the lung parenchyma. MCTC accumulate in the lungs of infants with severe bronchopulmonary dysplasia (BPD), a chronic lung disease associated with preterm birth, which is characterized by pulmonary vascular dysmorphia. The human LUVA mast cell line was used to model MCTC or MCT. The ability of MCTC to affect vascular organization during fetal lung development was test...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
The relation between mechanical ventilation (MV) and bronchopulmonary dysplasia (BPD) - a common disease in extremely premature newborn (PTNB) - is well stabilished, but is unknown, however, how much time unde...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
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