Intermittent CPAP limits hyperoxia induced lung damage in a rabbit model of bronchopulmonary dysplasia.

Intermittent CPAP limits hyperoxia induced lung damage in a rabbit model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2020 Mar 18;: Authors: Gie AG, Salaets T, Vignero J, Regin Y, Vanoirbeek JA, Deprest J, Toelen J Abstract A significant proportion of preterm infants develop bronchopulmonary dysplasia (BPD) leading to poor lifelong respiratory health. Limited treatment options exist with continuous positive airway pressure ventilation (CPAP) being one of the few associated with diminished BPD. However, little is known on the effect of the distending pressure of CPAP on the developing lung exposed to hyperoxia. We aimed to identify the functional and structural effects of CPAP in the preterm hyperoxia rabbit model of BPD. Premature rabbit pups were randomized to normoxia, hyperoxia (≥95% O2) or hyperoxia plus 4 hours daily CPAP (FiO2 0.95, 5cm H2O). On day 7 post-delivery we performed invasive pressure-volume and forced oscillation based pulmonary function tests, prior to lung harvest for histological evaluation. Alveolar and vascular morphology, airway smooth muscle, respiratory epithelium height, extracellular matrix components and inflammatory cytokine expression were quantified. Hyperoxia-reared pups had restrictive lungs: alveolar walls were thickened, with the lung parenchymal tissue, collagen content and airway smooth muscle content increased. In addition, peripheral pulmonary artery wall thickness was i...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research